Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

35 questions · 36 findings · 5 reviews · Acute Respiratory Infections

No studies found 12 · 33.3%GRADE not reported 0 · 0%Very low 10 · 27.8%Low 9 · 25%Moderate 4 · 11.1%High 1 · 2.8%

Magnesium sulphate + epinephrine vs no treatment or normal saline + epinephrine

Length of hospital stay · children up to 12 months old with acute bronchiolitis

It is very uncertain whether magnesium sulphate + epinephrine changes duration of hospital stay compared with no treatment or normal saline + epinephrine (very low certainty).

1 finding from 1 review

Magnesium sulphate + epinephrine vs no treatment or normal saline + epinephrine

Clinical severity score (CSS) (RDAI score; range 0 to 17; higher = poorer outcomes) measured at 0 to 24 hoursafter treatment · children up to 12 months old with acute bronchiolitis

It is very uncertain whether magnesium sulphate + epinephrine changes clinical severity score (CSS) (RDAI score; range 0 to 17; higher =… compared with no treatment or normal saline + epinephrine (very low certainty).

1 finding from 1 review

Magnesium sulphate + epinephrine vs no treatment or normal saline + epinephrine

Clinical severity score (CSS) (RDAI score; range 0 to 17; higher = poorer outcomes) measured 25 to 48 hoursafter treatment · children up to 12 months old with acute bronchiolitis

It is very uncertain whether magnesium sulphate + epinephrine changes clinical severity score (CSS) (RDAI score; range 0 to 17; higher =… compared with no treatment or normal saline + epinephrine (very low certainty).

1 finding from 1 review

Gamma‐globulin vs control (no preparation or saline preparation)

Rubella cases Initial meta‐analysis ‐ clinical diagnosis or serology +/‐ virus isolation +/‐ clinical signs · susceptible people exposed to rubella

Gamma‐globulin probably leads to lower rubella cases Initial meta‐analysis ‐ clinical diagnosis or serology… compared with control (saline or no treatment) (moderate certainty).

1 finding from 1 review

Gamma‐globulin vs control (no preparation or saline preparation)

Subgroup: rubella cases Estimated dose 0.027 to 0.037 ml/lb11 Clinical diagnosis by 2 physicians · susceptible people exposed to rubella

Gamma‐globulin showed no clear difference in subgroup: rubella cases Estimated dose 0.027 to 0.037 ml/lb11… compared with control (saline or no treatment) (low certainty).

1 finding from 1 review

Gamma‐globulin vs control (no preparation or saline preparation)

Subgroup: rubella cases Estimated dose 0.1 to 0.15 ml/lb11 Serology +/‐ virus isolation +/‐ clinical signs · susceptible people exposed to rubella

Gamma‐globulin leads to lower subgroup: rubella cases Estimated dose 0.1 to 0.15 ml/lb11 Serology… compared with control (saline or no treatment) (high certainty).

1 finding from 1 review

Gamma‐globulin vs control (no preparation or saline preparation)

Subgroup: rubella cases Estimated dose 0.2 to 0.5 ml/lb11 Serology +/‐ virus isolation +/‐ clinical signs · susceptible people exposed to rubella

Gamma‐globulin showed no clear difference in subgroup: rubella cases Estimated dose 0.2 to 0.5 ml/lb11 Serology… compared with control (saline or no treatment) (moderate certainty).

1 finding from 1 review

Steam (mist) vs nebulised 0.9% saline

change in respiratory distress score at 30 minutes Scale from: 0 to 13. · patients with acute bronchiolitis in children up to three years of age
2 findings from 1 review