Findings

What do systematic reviews say?

28 questions · 28 findings · 2 reviews · Pain, Palliative and Supportive Care

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No studies found 4 · 14.3%GRADE not reported 1 · 3.6%Very low 9 · 32.1%Low 14 · 50%Moderate 0 · 0%High 0 · 0%

SSRIs or SNRIs vs placebo

Headache intensity (mean score) · patients with tension‐type headache

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Low

SSRIs or SNRIs vs placebo

Headache duration (hours) · patients with tension‐type headache

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Low

SSRIs or SNRIs vs placebo

Symptomatic/analgesic medication use for acute headache attacks · patients with tension‐type headache

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 118 participants
Low

SSRIs or SNRIs vs placebo

Headache index · patients with tension‐type headache

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 128 participants
Very low

SSRIs or SNRIs vs placebo

Quality of life · patients with tension‐type headache

The review found no eligible studies for this question.

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

SSRIs or SNRIs vs placebo

Withdrawals due to adverse events · patients with tension‐type headache

It is very uncertain whether SSRIs or SNRIs changes withdrawals due to adverse events compared with placebo (very low certainty).

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
OR 3.72 [0.79, 17.53]
3 studies · 190 participants
Very low

SSRIs or SNRIs vs other antidepressants

Headache (frequency) · patients with tension‐type headache

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 152 participants
Very low

SSRIs or SNRIs vs other antidepressants

Headache intensity (mean score) · patients with tension‐type headache

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 152 participants
Very low