Findings

What do systematic reviews say?

65 questions · 66 findings · 8 reviews

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No studies found 2 · 3%GRADE not reported 6 · 9.1%Very low 25 · 37.9%Low 21 · 31.8%Moderate 9 · 13.6%High 3 · 4.5%

Selective serotonin reuptake inhibitors vs placebo

PSG sleep outcomes (at 12 weeks) · adults with insomnia

1 finding from 1 review

Antidepressants for insomnia in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Very low

Selective serotonin reuptake inhibitors vs benzodiazepines

Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder

It is very uncertain whether SSRIs changes failure to respond compared with benzodiazepines (very low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 0.93 [0.48, 1.8]
1 study · 154 participants
Very low

Selective serotonin reuptake inhibitors vs benzodiazepines

Leaving the study early · adults with panic disorder

It is very uncertain whether SSRIs changes total number of dropouts compared with benzodiazepines (very low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.71 [1.03, 2.84]
1 study · 154 participants
Very low

Selective serotonin reuptake inhibitors vs benzodiazepines

Failure to remit at endpoint · adults with panic disorder

It is very uncertain whether SSRIs changes failure to remit compared with benzodiazepines (very low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.12 [0.79, 1.59]
1 study · 154 participants
Very low

Selective serotonin reuptake inhibitors vs benzodiazepines

panic symptoms · adults with panic disorder

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 146 participants
Low

Selective serotonin reuptake inhibitors vs benzodiazepines

Withdrawals due to adverse events · adults with panic disorder

It is very uncertain whether SSRIs changes number of dropouts due to adverse effects compared with benzodiazepines (very low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.2 [0.55, 2.61]
1 study · 154 participants
Very low

Selective serotonin reuptake inhibitors vs MAOI

Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder

SSRIs showed no clear difference in failure to respond compared with MAOIs (moderate certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.12 [0.83, 1.52]
2 studies · 396 participants
Moderate

Selective serotonin reuptake inhibitors vs MAOI

Leaving the study early · adults with panic disorder

SSRIs showed no clear difference in total number of dropouts compared with MAOIs (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1 [0.07, 14.55]
1 study · 30 participants
Low

Selective serotonin reuptake inhibitors vs MAOI

Failure to remit at endpoint · adults with panic disorder

SSRIs showed no clear difference in failure to remit compared with MAOIs (moderate certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 0.93 [0.74, 1.17]
1 study · 366 participants
Moderate

Selective serotonin reuptake inhibitors vs MAOI

panic symptoms · adults with panic disorder

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Selective serotonin reuptake inhibitors vs MAOI

Withdrawals due to adverse events · adults with panic disorder

SSRIs showed no clear difference in number of dropouts due to adverse events compared with MAOIs (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.26 [0.59, 2.7]
1 study · 366 participants
Low

Selective serotonin reuptake inhibitors vs SNRIs

Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder

SSRIs showed no clear difference in failure to respond compared with SNRIs (high certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 0.96 [0.75, 1.23]
2 studies · 991 participants
High

Selective serotonin reuptake inhibitors vs SNRIs

Leaving the study early · adults with panic disorder

SSRIs showed no clear difference in total number of dropouts compared with SNRIs (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.11 [0.74, 1.65]
2 studies · 991 participants
Low

Selective serotonin reuptake inhibitors vs SNRIs

Failure to remit at endpoint · adults with panic disorder

SSRIs showed no clear difference in failure to remit compared with SNRIs (high certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.05 [0.91, 1.21]
2 studies · 991 participants
High

Selective serotonin reuptake inhibitors vs SNRIs

panic symptoms · adults with panic disorder

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 945 participants
High

Selective serotonin reuptake inhibitors vs SNRIs

Withdrawals due to adverse events · adults with panic disorder

SSRIs showed no clear difference in number of dropouts due to adverse effects compared with SNRIs (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.86 [0.49, 7.05]
2 studies · 991 participants
Low

Selective serotonin reuptake inhibitors vs NaSSAs

Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Selective serotonin reuptake inhibitors vs NaSSAs

Leaving the study early · adults with panic disorder

SSRIs showed no clear difference in total number of dropouts compared with naSSAs (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.5 [0.29, 7.73]
1 study · 30 participants
Low

Selective serotonin reuptake inhibitors vs NaSSAs

Failure to remit at endpoint · adults with panic disorder

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Selective serotonin reuptake inhibitors vs NaSSAs

panic symptoms · adults with panic disorder

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 22 participants
Low