Findings

What do systematic reviews say?

31 questions · 32 findings · 5 reviews · Breast Cancer

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No studies found 0 · 0%GRADE not reported 5 · 15.6%Very low 2 · 6.3%Low 8 · 25%Moderate 11 · 34.4%High 6 · 18.8%

Exercise vs control

Cancer site‐specific quality of life · women receiving adjuvant therapy (chemo‐ or radiotherapy or both) for breast cancer

1 finding from 1 review

Exercise for women receiving adjuvant therapy for breast cancer 2016 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 262 participants
Low

Exercise vs control

Depression · women receiving adjuvant therapy (chemo‐ or radiotherapy or both) for breast cancer

1 finding from 1 review

Exercise for women receiving adjuvant therapy for breast cancer 2016 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 674 participants
Moderate

Exercise vs control

Cognitive function · women receiving adjuvant therapy (chemo‐ or radiotherapy or both) for breast cancer

1 finding from 1 review

Exercise for women receiving adjuvant therapy for breast cancer 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 213 participants
Low

Exercise vs control

Adverse events: lymphoedema · women receiving adjuvant therapy (chemo‐ or radiotherapy or both) for breast cancer

1 finding from 1 review

Exercise for women receiving adjuvant therapy for breast cancer 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 436 participants
Low

Summary of Findings Table ‐ PBI?APBI vs WBRT

Local recurrence‐free survival · health problem or population

Summary of Findings Table ‐ PBI?APBI probably leads to higher local recurrence‐free survival ‐ total (LR‐FS) compared with WBRT (moderate certainty).

1 finding from 1 review

Partial breast irradiation versus whole breast radiotherapy for early breast cancer 2021 · Cochrane Headline outcomes only
HR 1.21 [1.03, 1.42]
8 studies · 13168 participants
Moderate

Summary of Findings Table ‐ PBI?APBI vs WBRT

Cosmesis · health problem or population

Summary of Findings Table ‐ PBI?APBI probably leads to higher cosmesis, physician/nurse‐reported compared with WBRT (moderate certainty).

1 finding from 1 review

Partial breast irradiation versus whole breast radiotherapy for early breast cancer 2021 · Cochrane Headline outcomes only
OR 1.57 [1.31, 1.87]
6 studies · 3652 participants
Moderate

Summary of Findings Table ‐ PBI?APBI vs WBRT

Overall survival · health problem or population

Summary of Findings Table ‐ PBI?APBI showed no clear difference in overall survival compared with WBRT (high certainty).

1 finding from 1 review

Partial breast irradiation versus whole breast radiotherapy for early breast cancer 2021 · Cochrane Headline outcomes only
HR 0.99 [0.88, 1.12]
8 studies · 13175 participants
High

Summary of Findings Table ‐ PBI?APBI vs WBRT

Late radiotherapy toxicity (subcutaneous fibrosis) · health problem or population

Summary of Findings Table ‐ PBI?APBI probably leads to higher subcutaneous fibrosis (late RT toxicity) compared with WBRT (moderate certainty).

1 finding from 1 review

Partial breast irradiation versus whole breast radiotherapy for early breast cancer 2021 · Cochrane Headline outcomes only
OR 5.07 [3.81, 6.74]
2 studies · 3011 participants
Moderate

Summary of Findings Table ‐ PBI?APBI vs WBRT

Disease‐specific survival · health problem or population

Summary of Findings Table ‐ PBI?APBI showed no clear difference in cause‐specific survival (C‐SS) compared with WBRT (moderate certainty).

1 finding from 1 review

Partial breast irradiation versus whole breast radiotherapy for early breast cancer 2021 · Cochrane Headline outcomes only
HR 1.06 [0.83, 1.36]
7 studies · 9865 participants
Moderate

Summary of Findings Table ‐ PBI?APBI vs WBRT

Distant metastasis‐free survival · health problem or population

Summary of Findings Table ‐ PBI?APBI showed no clear difference in distant metastasis‐free survival (DM‐FS) compared with WBRT (moderate certainty).

1 finding from 1 review

Partial breast irradiation versus whole breast radiotherapy for early breast cancer 2021 · Cochrane Headline outcomes only
HR 0.95 [0.8, 1.13]
7 studies · 11033 participants
Moderate

Summary of Findings Table ‐ PBI?APBI vs WBRT

Subsequent mastectomy · health problem or population

Summary of Findings Table ‐ PBI?APBI showed no clear difference in subsequent mastectomy compared with WBRT (high certainty).

1 finding from 1 review

Partial breast irradiation versus whole breast radiotherapy for early breast cancer 2021 · Cochrane Headline outcomes only
OR 0.98 [0.78, 1.23]
3 studies · 3740 participants
High