Findings

What do systematic reviews say?

136 questions · 136 findings · 10 reviews

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No studies found 46 · 33.8%GRADE not reported 15 · 11%Very low 44 · 32.4%Low 22 · 16.2%Moderate 8 · 5.9%High 1 · 0.7%

Prone horizontal vs prone head elevated positioning

Episodes of oxygen desaturation · spontaneously breathing preterm infants with apnoea

1 finding from 1 review

Body positioning for spontaneously breathing preterm infants with apnoea 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 111 participants
Very low

Prone horizontal vs prone head elevated positioning

Episodes of severe apnoea · spontaneously breathing preterm infants with apnoea

1 finding from 1 review

Body positioning for spontaneously breathing preterm infants with apnoea 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 87 participants
Very low

Prone horizontal vs prone head elevated positioning

Episodes of bradycardia · spontaneously breathing preterm infants with apnoea

1 finding from 1 review

Body positioning for spontaneously breathing preterm infants with apnoea 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 111 participants
Low

Prone horizontal vs prone head elevated positioning

Episodes of severe bradycardia · spontaneously breathing preterm infants with apnoea

1 finding from 1 review

Body positioning for spontaneously breathing preterm infants with apnoea 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 111 participants
Low

Combined deferasirox and deferiprone vs deferiprone and deferoxamine

Mortality at any time point · people with transfusion‐dependent thalassemia

1 finding from 1 review

Deferasirox for managing iron overload in people with thalassaemia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 96 participants
Low

Combined deferasirox and deferiprone vs deferiprone and deferoxamine

Responder analysis · people with transfusion‐dependent thalassemia

The review found no eligible studies for this question.

1 finding from 1 review

Deferasirox for managing iron overload in people with thalassaemia 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Combined deferasirox and deferiprone vs deferiprone and deferoxamine

Serum ferritin (ng/mL): mean change from baseline · people with transfusion‐dependent thalassemia

1 finding from 1 review

Deferasirox for managing iron overload in people with thalassaemia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 96 participants
Very low

Combined deferasirox and deferiprone vs deferiprone and deferoxamine

LIC · people with transfusion‐dependent thalassemia

1 finding from 1 review

Deferasirox for managing iron overload in people with thalassaemia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 96 participants
Low

Combined deferasirox and deferiprone vs deferiprone and deferoxamine

Satisfaction · people with transfusion‐dependent thalassemia

The review found no eligible studies for this question.

1 finding from 1 review

Deferasirox for managing iron overload in people with thalassaemia 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Combined deferasirox and deferiprone vs deferiprone and deferoxamine

Adherence: Discontinuations · people with transfusion‐dependent thalassemia

1 finding from 1 review

Deferasirox for managing iron overload in people with thalassaemia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 96 participants
Very low

Combined deferasirox and deferiprone vs deferiprone and deferoxamine

Drug‐related AE: serum creatinine increased (≥ 33%) above baseline in 2 consecutive occasions · people with transfusion‐dependent thalassemia

It is very uncertain whether deferasirox and deferiprone changes drug‐related AE: serum creatinine increased (≥ 33%) above baseline… compared with deferiprone and deferoxamine (very low certainty).

1 finding from 1 review

Deferasirox for managing iron overload in people with thalassaemia 2017 · Cochrane Headline outcomes only
RR 3 [0.32, 27.83]
1 study · 96 participants
Very low

Combined deferasirox and deferiprone vs deferiprone

Mortality at any time point · people with transfusion‐dependent thalassemia

1 finding from 1 review

Deferasirox for managing iron overload in people with thalassaemia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 participants
GRADE not reported

Combined deferasirox and deferiprone vs deferiprone

Responder analysis · people with transfusion‐dependent thalassemia

1 finding from 1 review

Deferasirox for managing iron overload in people with thalassaemia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 participants
GRADE not reported

Combined deferasirox and deferiprone vs deferiprone

Serum ferritin (ng/mL) · people with transfusion‐dependent thalassemia

1 finding from 1 review

Deferasirox for managing iron overload in people with thalassaemia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 participants
GRADE not reported

Combined deferasirox and deferiprone vs deferiprone

LIC · people with transfusion‐dependent thalassemia

1 finding from 1 review

Deferasirox for managing iron overload in people with thalassaemia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 participants
GRADE not reported

Combined deferasirox and deferiprone vs deferiprone

Satisfaction with treatment · people with transfusion‐dependent thalassemia

1 finding from 1 review

Deferasirox for managing iron overload in people with thalassaemia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 participants
GRADE not reported

Combined deferasirox and deferiprone vs deferiprone

Adherence · people with transfusion‐dependent thalassemia

1 finding from 1 review

Deferasirox for managing iron overload in people with thalassaemia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 participants
GRADE not reported

Combined deferasirox and deferiprone vs deferiprone

AE: Serum creatinine increase · people with transfusion‐dependent thalassemia

1 finding from 1 review

Deferasirox for managing iron overload in people with thalassaemia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 participants
GRADE not reported

Mortality: prone position vs supine

Short‐term mortality (STM)Alive or dead · adults with acute respiratory failure

Mortality: prone position showed no clear difference in short‐term mortality (STM)Alive or dead compared with supine (low certainty).

1 finding from 1 review

Prone position for acute respiratory failure in adults 2015 · Cochrane Headline outcomes only
RR 0.84 [0.69, 1.02]
8 studies · 2117 participants
Low

Mortality: prone position vs supine

Longer‐term mortality (LTM)Alive or dead · adults with acute respiratory failure

Mortality: prone position showed no clear difference in longer‐term mortality (LTM)Alive or dead compared with supine (low certainty).

1 finding from 1 review

Prone position for acute respiratory failure in adults 2015 · Cochrane Headline outcomes only
RR 0.86 [0.72, 1.03]
8 studies · 2141 participants
Low