Findings

What do systematic reviews say?

211 questions · 253 findings · 24 reviews · Oral and maxillofacial surgery

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No studies found 32 · 12.6%GRADE not reported 183 · 72.3%Very low 25 · 9.9%Low 7 · 2.8%Moderate 6 · 2.4%High 0 · 0%

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability, adjusted for DMFS

Femur fracture · European GWAS participants

The MVMR MR-Egger interval included the null.

1 finding from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · MVMR MR-Egger
OR 1.024 [0.960, 1.093]
489106 participants
GRADE not reported

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability, adjusted for DMFS

Postmenopausal osteoporosis with pathological fracture · European GWAS participants

The MVMR MR-Egger interval included the null.

1 finding from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · MVMR MR-Egger
OR 1.012 [0.858, 1.193]
281786 participants
GRADE not reported

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability, adjusted for DMFS

Osteoporosis with pathological fracture · European GWAS participants

The MVMR MR-Egger interval included the null.

1 finding from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · MVMR MR-Egger
OR 1.002 [0.867, 1.158]
376746 participants
GRADE not reported

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability

Bone mineral density in forearm · European-ancestry adults

Genetically predicted periodontitis had no causal effect on forearm BMD.

1 finding from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Lifelong genetic liability · European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD) · SVMR and MVMR (IVW)
No causal effect of oral diseases on FA-BMD was found (SVMR and MVMR); no numeric estimate reported in text (see Fig. 3).
8143 participants
GRADE not reported

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability

Lumbar spine bone mineral density (BMD) · European GWAS participants

The SVMR IVW interval excluded zero.

1 finding from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR IVW
BETA 0.055 [0.008, 0.102]
28498 participants
GRADE not reported

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability

Forearm fracture · European-ancestry adults

Genetically predicted periodontitis had no causal effect on fracture of forearm (multivariable MR, OR 0.995).

2 findings from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Lifelong genetic liability · European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD) · MVMR (IVW), adjusted for DMFS
OR 0.995 [0.953, 1.039]
490889 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Lifelong genetic liability · European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD) · SVMR (IVW), total causal effect
OR 0.990 [0.951, 1.031]
490889 participants
GRADE not reported

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability

Femur fracture · European GWAS participants

The SVMR Weighted Median interval included the null.

3 findings from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR Weighted Median
OR 1.055 [0.979, 1.136]
489106 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR Maximum Likelihood
OR 1.044 [0.983, 1.109]
489106 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR MR-Egger
OR 1.063 [0.991, 1.140]
489106 participants
GRADE not reported

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability

Postmenopausal osteoporosis with pathological fracture · European GWAS participants

The SVMR Weighted Median interval included the null.

3 findings from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR Weighted Median
OR 0.979 [0.826, 1.159]
281786 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR Maximum Likelihood
OR 1.014 [0.872, 1.179]
281786 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR MR-Egger
OR 0.934 [0.786, 1.111]
281786 participants
GRADE not reported

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability

Postmenopausal osteoporosis with pathological fracture · Postmenopausal women (European ancestry)

Genetically predicted periodontitis had no causal effect on postmenopausal osteoporosis with pathological fracture (single-variable MR, OR 1.014).

2 findings from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Lifelong genetic liability · European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD) · SVMR (IVW), total causal effect
OR 1.014 [0.857, 1.199]
281786 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Lifelong genetic liability · European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD) · MVMR (IVW), adjusted for DMFS
OR 1.016 [0.867, 1.191]
281786 participants
GRADE not reported

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability, adjusted for DMFS

Osteoporosis · European GWAS participants

The MVMR MR-Egger interval included the null.

1 finding from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · MVMR MR-Egger
OR 1.005 [0.940, 1.074]
483725 participants
GRADE not reported

Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS, adjusted for periodontitis

Femur fracture · European GWAS participants

The MVMR MR-Egger interval included the null.

1 finding from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · MVMR MR-Egger
OR 0.820 [0.618, 1.087]
489106 participants
GRADE not reported

Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS, adjusted for periodontitis

Forearm fracture · European GWAS participants

The MVMR MR-Egger interval included the null.

1 finding from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · MVMR MR-Egger
OR 0.901 [0.751, 1.081]
490889 participants
GRADE not reported

Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS

Postmenopausal osteoporosis with pathological fracture · European GWAS participants

The SVMR Maximum Likelihood interval included the null.

3 findings from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR Maximum Likelihood
OR 1.363 [0.955, 1.947]
281786 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR MR-Egger
OR 1.355 [0.696, 2.635]
281786 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR Weighted Median
OR 1.214 [0.746, 1.977]
281786 participants
GRADE not reported

Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS

Osteoporosis with pathological fracture · European GWAS participants

The SVMR MR-Egger interval included the null.

3 findings from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR MR-Egger
OR 1.097 [0.598, 2.011]
376746 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR Weighted Median
OR 1.181 [0.748, 1.866]
376746 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR Maximum Likelihood
OR 1.278 [0.921, 1.773]
376746 participants
GRADE not reported

Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS

Femur fracture · European GWAS participants

The SVMR MR-Egger interval included the null.

3 findings from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR MR-Egger
OR 0.893 [0.678, 1.175]
489106 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR Maximum Likelihood
OR 1.137 [0.976, 1.325]
489106 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR Weighted Median
OR 1.094 [0.884, 1.354]
489106 participants
GRADE not reported

Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS

Lumbar spine and pelvis fracture · European GWAS participants

The SVMR Weighted Median interval included the null.

3 findings from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR Weighted Median
OR 0.867 [0.691, 1.087]
490700 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR Maximum Likelihood
OR 0.950 [0.808, 1.117]
490700 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR MR-Egger
OR 0.994 [0.729, 1.355]
490700 participants
GRADE not reported

Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS, adjusted for periodontitis

Osteoporosis · European GWAS participants

The MVMR MR-Egger interval excluded the null.

1 finding from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · MVMR MR-Egger
OR 1.343 [1.015, 1.778]
483725 participants
GRADE not reported

Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS

Lumbar spine bone mineral density (BMD) · European GWAS participants

The SVMR IVW interval excluded zero.

1 finding from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR IVW
BETA 0.105 [0.006, 0.205]
28498 participants
GRADE not reported

Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS

Osteoporosis · European GWAS participants

The SVMR Weighted Median interval excluded the null.

3 findings from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR Weighted Median
OR 1.260 [1.017, 1.560]
483725 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR Maximum Likelihood
OR 1.162 [0.998, 1.353]
483725 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR MR-Egger
OR 1.329 [0.991, 1.782]
483725 participants
GRADE not reported

Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS, adjusted for periodontitis

Lumbar spine and pelvis fracture · European GWAS participants

The MVMR MR-Egger interval included the null.

1 finding from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · MVMR MR-Egger
OR 1.034 [0.769, 1.390]
490700 participants
GRADE not reported