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What do systematic reviews say?

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Evidence found and GRADE certainty

71 questions · 80 findings · 13 reviews · Metabolic and Endocrine Disorders

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No studies found 24 · 30%GRADE not reported 0 · 0%Very low 24 · 30%Low 13 · 16.3%Moderate 15 · 18.8%High 4 · 5%

Testosterone vs placebo

Withdrawals due to adverse events · men with sexual dysfunction

It is very uncertain whether testosterone changes treatment withdrawal due to adverse events compared with placebo (very low certainty).

2 findings from 1 review

Summary of findings: pioglitazone monotherapy vs placebo

Incidence of T2DM (N) · people at increased risk for developing type 2 diabetes

Summary of findings: pioglitazone monotherapy may leads to lower incidence of T2DM (N) Diagnostic criteria: 3 studies applied the WHO… compared with placebo (low certainty).

1 finding from 1 review

Summary of findings: pioglitazone monotherapy vs placebo

Cardiovascular mortality · people at increased risk for developing type 2 diabetes

It is very uncertain whether summary of findings: pioglitazone monotherapy changes cardiovascular mortality (N) compared with placebo (very low certainty).

1 finding from 1 review

Summary of findings: pioglitazone monotherapy vs placebo

Non‐fatal myocardial infarction/stroke · people at increased risk for developing type 2 diabetes

It is very uncertain whether summary of findings: pioglitazone monotherapy changes non‐fatal myocardial infarction/stroke (N) compared with placebo (very low certainty).

1 finding from 1 review

Fluoxetine vs placebo

Any adverse event (N) · overweight or obese adults

Summary of findings: fluoxetine showed no clear difference in any adverse event (N) compared with placebo (low certainty).

1 finding from 1 review