Zinc vs placebo
Haemoglobin status · people with sickle cell disease
Zinc may leads to higher haemoglobin status (g/dL) compared with placebo (low certainty).
1 finding from 1 review
- MD 1.26 [0.44, 1.26]1 study · 36 participantsLow
Findings
What do systematic reviews say?
697 questions · 708 findings · 47 reviews · Cystic Fibrosis and Genetic Disorders
No studies found 263 · 37.1%GRADE not reported 12 · 1.7%Very low 146 · 20.6%Low 168 · 23.7%Moderate 98 · 13.8%High 21 · 3%
N‐acetylcysteine (1200 mg) vs placebo
Frequency of crisis (number of pain days) · sickle cell disease
N‐acetylcysteine (1200 mg) showed no clear difference in frequency of crisis (number of pain days) compared with placebo (low certainty).
1 finding from 1 review
- Rate ratio 0.99 [0.53, 1.84]1 study · 96 participantsLow
N‐acetylcysteine (1200 mg) vs placebo
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · sickle cell disease
N‐acetylcysteine (1200 mg) showed no clear difference in severity of pain (maximum pain intensity on pain days) compared with placebo (low certainty).
1 finding from 1 review
- MD 0.171 study · 96 participantsLow
N‐acetylcysteine (1200 mg) vs placebo
QoL of participants living with SCD and their caregivers · sickle cell disease
It is very uncertain whether N‐acetylcysteine (1200 mg) changes qoL of participants living with SCD and their caregivers (measured… compared with placebo (very low certainty).
1 finding from 1 review
- no estimate extracted1 study · 96 participantsVery low
N‐acetylcysteine (1200 mg) vs placebo
Adverse effects · sickle cell disease
N‐acetylcysteine (1200 mg) showed no clear difference in adverse effects compared with placebo (low certainty).
1 finding from 1 review
- RR 0.92 [0.75, 1.14]1 study · 96 participantsLow
N‐acetylcysteine (1200 mg) vs placebo
Frequency of hospitalization · sickle cell disease
N‐acetylcysteine (1200 mg) may leads to lower frequency of hospitalization compared with placebo (low certainty).
1 finding from 1 review
- rate ratio 0.981 study · 96 participantsLow
Vitamin C 1400 mg plus vitamin E 800 mg vs placebo
Severity of pain (use of opioid analgesics) · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)
It is very uncertain whether vitamin C 1400 mg plus vitamin E 800 mg changes severity of pain (use of opioid analgesics) compared with placebo (very low certainty).
1 finding from 1 review
- RR 1.33 [0.4, 4.37]1 study · 83 participantsVery low
N‐acetylcysteine (1200 mg) vs placebo
Acute chest syndrome ( · sickle cell disease
It is very uncertain whether N‐acetylcysteine (1200 mg) changes frequency of sickle cell‐related complications (acute chest syndrome) compared with placebo (very low certainty).
1 finding from 1 review
- RR 5 [0.25, 101.48]1 study · 96 participantsVery low
N‐acetylcysteine (1200 mg) vs placebo
Haemoglobin status · sickle cell disease
N‐acetylcysteine (1200 mg) showed no clear difference in haemoglobin status compared with placebo (low certainty).
1 finding from 1 review
- no estimate extracted1 study · 96 participantsLow
L‐arginine vs placebo
Frequency of crisis · sickle cell disease
L‐arginine showed no clear difference in frequency of crisis (monthly crisis) compared with placebo (low certainty).
1 finding from 1 review
- RR 0.71 [0.26, 1.95]1 study · 50 participantsLow
L‐arginine vs placebo
Pain 0 to 100 visual analogue scale and 10‐point Likert scale (lower score = less pain) · sickle cell disease
L‐arginine showed no clear difference in severity of pain (assessed using a 10‐cm visual analogue scale from… compared with placebo (low certainty).
1 finding from 1 review
- no estimate extracted2 studies · 125 participantsLow
L‐arginine vs placebo
QoL of participants living with SCD and their caregivers · sickle cell disease
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
L‐arginine vs placebo
Adverse effects · sickle cell disease
1 finding from 1 review
- no estimate extracted2 studies · 125 participantsGRADE not reported
L‐arginine vs placebo
Frequency of hospitalization (number of days in hospital) · sickle cell disease
It is very uncertain whether L‐arginine changes frequency of hospitalization (number of days in hospital) compared with placebo (very low certainty).
1 finding from 1 review
- no estimate extracted2 studies · 125 participantsVery low
L‐arginine vs placebo
Frequency of sickle cell‐related complications · sickle cell disease
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
L‐arginine vs placebo
Haemoglobin status · sickle cell disease
L‐arginine showed no clear difference in haemoglobin status (g/dL) compared with placebo (low certainty).
1 finding from 1 review
- MD 0.42 studies · 106 participantsLow
Omega‐3 vs placebo
Frequency of crisis · sickle cell disease
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Vitamin C 1400 mg plus vitamin E 800 mg vs placebo
QoL of participants living with SCD and their caregivers · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Omega‐3 vs placebo
Severity of pain · sickle cell disease
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Omega‐3 vs placebo
QoL of participants living with SCD and their caregivers · sickle cell disease
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found