Findings

What do systematic reviews say?

537 questions · 560 findings · 45 reviews · Common Mental Disorders

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No studies found 105 · 18.8%GRADE not reported 8 · 1.4%Very low 170 · 30.4%Low 153 · 27.3%Moderate 94 · 16.8%High 30 · 5.4%

Tricyclic antidepressants vs placebo

Failure to remit at endpoint · adults with panic disorder

Tricyclic antidepressants may leads to lower failure to remit compared with placebo (low certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 0.82 [0.69, 0.99]
8 studies · 1294 participants
Low

Tricyclic antidepressants vs placebo

panic symptoms · adults with panic disorder

2 findings from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 1247 participants
Moderate
Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 70 participants
Very low

Tricyclic antidepressants vs placebo

Withdrawals due to adverse events · adults with panic disorder

Tricyclic antidepressants probably leads to higher number of dropouts due to adverse effects compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 1.97 [1.33, 2.91]
10 studies · 1641 participants
Moderate

Selective serotonin reuptake inhibitors vs placebo

Outcomes (2‐6 months post‐treatment) · adults with panic disorder

The review found no eligible studies for this question.

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Selective serotonin reuptake inhibitors vs placebo

Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder

Selective serotonin reuptake inhibitors may leads to lower failure to respond compared with placebo (low certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 0.75 [0.67, 0.84]
21 studies · 4000 participants
Low

Selective serotonin reuptake inhibitors vs placebo

Leaving the study early · adults with panic disorder

Selective serotonin reuptake inhibitors showed no clear difference in total number of dropouts compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 0.99 [0.9, 1.09]
23 studies · 4302 participants
Moderate

Selective serotonin reuptake inhibitors vs placebo

Failure to remit at endpoint · adults with panic disorder

Selective serotonin reuptake inhibitors probably leads to lower failure to remit compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 0.81 [0.75, 0.88]
16 studies · 3339 participants
Moderate

Selective serotonin reuptake inhibitors vs placebo

panic symptoms · adults with panic disorder

2 findings from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 1625 participants
Moderate
Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 1255 participants
Moderate

Antidepressants vs placebo

Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder

Antidepressants may leads to lower failure to respond compared with placebo (low certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 0.72 [0.66, 0.79]
30 studies · 6500 participants
Low

Selective serotonin reuptake inhibitors vs placebo

Withdrawals due to adverse events · adults with panic disorder

Selective serotonin reuptake inhibitors probably leads to higher number of dropouts due to adverse effects compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 1.45 [1.16, 1.81]
22 studies · 4131 participants
Moderate

Serotonin and noradrenaline reuptake inhibitors (SNRI) vs placebo

Outcomes (2‐6 months post‐treatment) · adults with panic disorder

The review found no eligible studies for this question.

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Serotonin and noradrenaline reuptake inhibitors (SNRI) vs placebo

Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder

Serotonin‐norepinephrine reuptake inhibitors may leads to lower failure to respond compared with placebo (low certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 0.61 [0.41, 0.91]
4 studies · 1531 participants
Low

Serotonin and noradrenaline reuptake inhibitors (SNRI) vs placebo

Leaving the study early · adults with panic disorder

Serotonin‐norepinephrine reuptake inhibitors showed no clear difference in total number of dropouts compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 0.93 [0.69, 1.26]
4 studies · 1531 participants
Moderate

Serotonin and noradrenaline reuptake inhibitors (SNRI) vs placebo

Failure to remit at endpoint · adults with panic disorder

Serotonin‐norepinephrine reuptake inhibitors probably leads to lower failure to remit compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 0.84 [0.75, 0.95]
4 studies · 1531 participants
Moderate

Serotonin and noradrenaline reuptake inhibitors (SNRI) vs placebo

panic symptoms · adults with panic disorder

2 findings from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 723 participants
High
Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 685 participants
High

Serotonin and noradrenaline reuptake inhibitors (SNRI) vs placebo

Withdrawals due to adverse events · adults with panic disorder

Serotonin‐norepinephrine reuptake inhibitors showed no clear difference in number of dropouts due to adverse effects compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 1.49 [0.92, 2.4]
4 studies · 1531 participants
Moderate

Antidepressants vs placebo

Leaving the study early · adults with panic disorder

Antidepressants probably leads to lower total number of dropouts compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 0.88 [0.81, 0.97]
38 studies · 7850 participants
Moderate

Antidepressants vs placebo

Failure to remit at endpoint · adults with panic disorder

Antidepressants probably leads to lower failure to remit compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 0.83 [0.78, 0.88]
24 studies · 6164 participants
Moderate

Antidepressants vs placebo

panic symptoms · adults with panic disorder

2 findings from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
15 studies · 3699 participants
Low
Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 2010 participants
Low

Antidepressants vs placebo

Withdrawals due to adverse events · adults with panic disorder

Antidepressants probably leads to higher number of dropouts due to adverse effects compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 1.49 [1.25, 1.78]
33 studies · 7688 participants
Moderate