Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

90 questions · 117 findings · 5 reviews · Oral Health

No studies found 33 · 28.2%GRADE not reported 51 · 43.6%Very low 18 · 15.4%Low 12 · 10.3%Moderate 3 · 2.6%High 0 · 0%

Oral propranolol vs placebo

Adverse events ‐ treatment emergent · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review

NSAID (systemic) vs paracetamol

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

NSAID (systemic) showed no clear difference in pain intensity (VAS 0-100 mm) compared with paracetamol (low certainty).

3 findings from 1 review

Topical NSAID (ketoprofen lysinate mouthwash, 160 mg) vs Topical NSAID (benzidamine hydrochloride mouthwash, 22.5 mg)

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
1 finding from 1 review

Topical NSAID (ketoprofen chewing gum) vs Local anaesthetic (benzocaine chewing gum)

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

It is very uncertain whether topical NSAID (ketoprofen chewing gum) changes pain intensity (VAS 0-100 mm) compared with local anaesthetic (benzocaine chewing gum) (very low certainty).

1 finding from 1 review

CBT vs No special instructions (control)

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Adults undergoing orthodontic treatment

Cognitive behavioural therapy (CBT) led to lower patient‐reported pain intensity or pain relief (VAS, NRS or… compared with no special instructions (control); GRADE not reported.

3 findings from 1 review

Low‐level laser therapy vs Placebo (or no irradiation)

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Adolescents and adults undergoing orthodontic treatment

Low‐level laser therapy (LLLT) showed no clear difference in patient‐reported pain intensity or pain relief (VAS, NRS or… compared with placebo (or no irradiation); GRADE not reported.

5 findings from 1 review
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