What do systematic reviews say?

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) vs paracetamol

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) led to higher patients using rescue medication at 8 hours compared with paracetamol (acetaminophen) (single postoperative oral dose; 600 mg…; GRADE not reported.

• Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes

  8 hours postdosing
  RR 2.02 [1.57, 2.60]
  2 studies
  GRADE not reported

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) vs paracetamol

• Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes

  Study period (immediate postoperative)
  The majority of adverse events were minor in nature and usually included nausea, vomiting, headaches and dizziness. Side effect profiles have not been included in a meta-analysis as multiple adverse events were…
  7 studies
  GRADE not reported

NSAID (systemic) vs paracetamol

It is very uncertain whether NSAID (systemic) changes rescue analgesia compared with paracetamol (very low certainty).

• Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
  RR 1.5 [0.6, 3.6]
  1 study · 159 participants
  Very low

NSAID (systemic) vs paracetamol

• Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
  In one study, one participant (<1%) in the paracetamol group experienced drug hypersensitivity (a 'red, blotchy and itchy rash') that resolved without treatment within 1 week (Bradley 2007 / McAlinden 2005); 1 RCT;…
  1 study
  Very low

NSAID (systemic) vs paracetamol

The review found no eligible studies for this question.

• Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
  No studies in this comparison reported this outcome.
  0 studies
  No studies found

NSAID (systemic) vs paracetamol

The review found no eligible studies for this question.

• Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
  No studies in this comparison reported this outcome.
  0 studies
  No studies found

NSAID (systemic) vs paracetamol

NSAID (systemic) showed no clear difference in pain intensity (VAS 0-100 mm) compared with paracetamol (low certainty).

• Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes

  6 hours
  MD -5.17 [-11.71, 1.37]
  7 studies · 664 participants
  Low
• Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes

  24 hours
  MD -0.51 [-8.93, 7.92]
  9 studies · 734 participants
  Low
• Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes

  2 hours
  MD -2.92 [-8.48, 2.65]
  7 studies · 664 participants
  Low

NSAID (systemic) vs paracetamol

The review found no eligible studies for this question.

• Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
  No studies in this comparison reported this outcome.
  0 studies
  No studies found