Findings

What do systematic reviews say?

26 questions · 32 findings · 4 reviews · Pain control and patient management

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No studies found 6 · 18.8%GRADE not reported 11 · 34.4%Very low 2 · 6.3%Low 4 · 12.5%Moderate 5 · 15.6%High 4 · 12.5%

NSAID (systemic) vs paracetamol

Rescue analgesia · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

It is very uncertain whether NSAID (systemic) changes rescue analgesia compared with paracetamol (very low certainty).

1 finding from 1 review

Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
RR 1.5 [0.6, 3.6]
1 study · 159 participants
Very low

NSAID (systemic) vs paracetamol

Adverse events · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

1 finding from 1 review

Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
In one study, one participant (<1%) in the paracetamol group experienced drug hypersensitivity (a 'red, blotchy and itchy rash') that resolved without treatment within 1 week (Bradley 2007 / McAlinden 2005); 1 RCT;…
1 study
Very low

NSAID (systemic) vs paracetamol

Time off school or work · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
No studies in this comparison reported this outcome.
0 studies
No studies found

NSAID (systemic) vs paracetamol

Quality of life or participant satisfaction · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
No studies in this comparison reported this outcome.
0 studies
No studies found

NSAID (systemic) vs paracetamol

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

NSAID (systemic) showed no clear difference in pain intensity (VAS 0-100 mm) compared with paracetamol (low certainty).

3 findings from 1 review

Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
6 hours
MD -5.17 [-11.71, 1.37]
7 studies · 664 participants
Low
Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
24 hours
MD -0.51 [-8.93, 7.92]
9 studies · 734 participants
Low
Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
2 hours
MD -2.92 [-8.48, 2.65]
7 studies · 664 participants
Low

NSAID (systemic) vs paracetamol

Failure to complete orthodontic treatment due to pain · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
No studies in this comparison reported this outcome.
0 studies
No studies found