Findings

What do systematic reviews say?

35 questions · 55 findings · 14 reviews · Dental caries

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No studies found 1 · 1.8%GRADE not reported 40 · 72.7%Very low 3 · 5.5%Low 10 · 18.2%Moderate 0 · 0%High 1 · 1.8%

Micro-invasive treatment (proximal sealing or resin infiltration): resin sealant, glass ionomer sealant, polyurethane/adhesive patch, or resin infiltration vs Non-invasive / control treatment

Material deficiency (retention/adaptation loss; re-treatment) · Dentate children and adults with non-cavitated proximal caries lesions extending into enamel or dentine (not pulp) in primary or permanent…

1 finding from 1 review

Micro‐invasive interventions for managing proximal dental decay in primary and permanent teeth 2015 · Cochrane All outcomes
3 years
One study (Alkilzy 2011, sealant patch) reported material deficiency: 10% total and 23% partial loss of proximal sealants after three years; 53% maintained perfect margins and none had open margins. No studies reported…
1 study
GRADE not reported

Resin composite restorations containing antibacterial agents vs Non-antibacterial containing composite restorations

Postoperative sensitivity, marginal adaptation, anatomic form and other clinical outcomes (USPHS restoration quality; includes tooth vitality and pulpitis) · Adults and adolescents in any age group with restorations in the permanent dentition and children with restorations in the primary dentition

The review found no eligible studies for this question.

1 finding from 1 review

Antibacterial agents in composite restorations for the prevention of dental caries 2013 · Cochrane All outcomes
No studies were included in this review, as we were unable to find any trials directly comparing antibacterial containing composites to other active interventions or controls.
0 studies
No studies found

Fluoride toothpaste vs Fluoride mouthrinse

Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less

Fluoride toothpaste showed no clear difference in unacceptability of treatment (drop-outs) compared with fluoride mouthrinse; GRADE not reported.

1 finding from 1 review

One topical fluoride (toothpastes, or mouthrinses, or gels, or varnishes) versus another for preventing dental caries… 2004 · Cochrane All outcomes
RR 0.89 [0.78, 1.00]
5 studies
GRADE not reported

Fluoride mouthrinse (0.05-0.32% sodium fluoride or amine fluoride) added to daily fluoride toothpaste vs Fluoride mouthrinse

Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less

Fluoride mouthrinse combined with fluoride toothpaste showed no clear difference in unacceptability of treatment (drop-outs / leaving study early) compared with fluoride mouthrinse alone; GRADE not reported.

1 finding from 1 review

Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
RR 0.88 [0.67, 1.17]
3 studies · 1697 participants
GRADE not reported

Fluoride gel combined with fluoride mouthrinse vs Fluoride gel

Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less

Fluoride gel combined with fluoride mouthrinse showed no clear difference in unacceptability of treatment (drop-outs / leaving study early) compared with fluoride gel alone; GRADE not reported.

1 finding from 1 review

Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
RR 1.00 [0.72, 1.40]
1 study · 344 participants
GRADE not reported

Fluoride varnish combined with fluoride toothpaste vs Fluoride varnish

Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less

Fluoride varnish combined with fluoride toothpaste showed no clear difference in unacceptability of treatment (drop-outs / leaving study early) compared with fluoride varnish alone; GRADE not reported.

1 finding from 1 review

Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
RR 0.75 [0.22, 2.59]
1 study · 196 participants
GRADE not reported

Fluoride varnish combined with fluoride toothpaste vs Fluoride toothpaste alone

Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less

Fluoride varnish combined with fluoride toothpaste showed no clear difference in unacceptability of treatment (drop-outs / leaving study early) compared with fluoride toothpaste alone; GRADE not reported.

1 finding from 1 review

Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
RR 1.29 [0.61, 2.71]
2 studies · 294 participants
GRADE not reported

Fluoride varnish vs Fluoride toothpaste alone

Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less

Fluoride varnish showed no clear difference in unacceptability of treatment (drop-outs) compared with fluoride toothpaste; GRADE not reported.

1 finding from 1 review

One topical fluoride (toothpastes, or mouthrinses, or gels, or varnishes) versus another for preventing dental caries… 2004 · Cochrane All outcomes
RR 1.28 [0.37, 4.41]
1 study
GRADE not reported

Fluoride mouthrinse, gel or varnish combined with fluoride toothpaste (any combined regimen) vs Fluoride toothpaste alone

Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less

Fluoride mouthrinse, gel or varnish combined with fluoride… showed no clear difference in unacceptability of treatment (drop-outs / leaving study early) compared with fluoride toothpaste alone; GRADE not reported.

1 finding from 1 review

Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
RR 1.06 [0.93, 1.22]
5 studies · 1998 participants
GRADE not reported

Fluoride toothpaste vs Any other topical fluoride (gel or mouthrinse)

Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less

Fluoride toothpaste showed no clear difference in unacceptability of treatment (drop-outs) compared with any other topical fluoride (gel or mouthrinse); GRADE not reported.

1 finding from 1 review

One topical fluoride (toothpastes, or mouthrinses, or gels, or varnishes) versus another for preventing dental caries… 2004 · Cochrane All outcomes
RR 0.88 [0.78, 1.00]
6 studies
GRADE not reported

Fluoride mouthrinse (0.05-0.32% sodium fluoride or amine fluoride) added to daily fluoride toothpaste vs Fluoride toothpaste alone

Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less

Fluoride mouthrinse combined with fluoride toothpaste showed no clear difference in unacceptability of treatment (drop-outs / leaving study early) compared with fluoride toothpaste alone; GRADE not reported.

1 finding from 1 review

Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
RR 1.03 [0.84, 1.26]
3 studies · 1704 participants
GRADE not reported

Fluoride varnish vs Fluoride mouthrinse

Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less

Fluoride varnish showed no clear difference in unacceptability of treatment (drop-outs) compared with fluoride mouthrinse; GRADE not reported.

1 finding from 1 review

One topical fluoride (toothpastes, or mouthrinses, or gels, or varnishes) versus another for preventing dental caries… 2004 · Cochrane All outcomes
RR 1.19 [0.86, 1.65]
2 studies
GRADE not reported

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

Unacceptability of treatment (dropouts/exclusions during the trial) · Children and adolescents aged 16 years or less

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish;… showed no clear difference in unacceptability of treatment (dropouts/exclusions during the trial) compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Topical fluoride (toothpastes, mouthrinses, gels or varnishes) for preventing dental caries in children and adolescents 2003 · Cochrane All outcomes
During trial · No-treatment-controlled trials
RR 1.20 [0.85, 1.70]
10 studies
GRADE not reported

Ion-releasing restoration, glass ionomer-based (conventional GIC, HV-GIC, RMGIC, glass hybrid) vs Resin composite restoration

Secondary caries · Patients with permanent dentition in need of restorations (all cavity types: Black's Class I, II, V, and non-carious cervical lesions)

Pooled across follow-up periods, ion-releasing (GIC) and resin composite restorations show no significant difference in secondary caries (RD -0.00, 95% CI -0.01 to 0.00; not separately GRADE-rated).

6 findings from 1 review

Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomes
Overall (1 year, 18 months-2 years, and 3 years pooled) · Permanent dentition; university (majority), school, and private-practice settings across multiple countries (Turkey, Brazil, Sweden, India, Vietnam, Belgium, Germany, etc.)
RD -0.00 [-0.01, 0.00]
12 studies · 3085 participants
GRADE not reported
Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomes
18 months-2 years · Permanent dentition; university (majority), school, and private-practice settings across multiple countries (Turkey, Brazil, Sweden, India, Vietnam, Belgium, Germany, etc.)
RD -0.00 [-0.01, 0.01]
8 studies · 1087 participants
Low
Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomes
1 year · University, private practice, primary school, and multicenter settings · All types of cavities
RD -0.00 [-0.01, 0.01]
12 studies · 1677 participants
Low

Show 3 more findings

Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomes
3 years · Permanent dentition; university (majority), school, and private-practice settings across multiple countries (Turkey, Brazil, Sweden, India, Vietnam, Belgium, Germany, etc.)
RD 0.00 [-0.02, 0.02]
3 studies · 321 participants
Low
Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomes
1 year · Permanent dentition; university (majority), school, and private-practice settings across multiple countries (Turkey, Brazil, Sweden, India, Vietnam, Belgium, Germany, etc.)
RD -0.00 [-0.01, 0.01]
12 studies · 1677 participants
Low
Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomes
18 months to 2 years · University, private practice, primary school, and multicenter settings · All types of cavities
RD -0.00 [-0.01, 0.01]
8 studies · 1087 participants
Low

Ion-releasing restoration (glass ionomer-based and compomer/polyacid-modified composite) vs Resin composite restoration

Secondary caries (caries around restorations), load-bearing cavities · Patients with permanent dentition in need of restorations in load-bearing cavities (Class I/II posterior)

In load-bearing cavities, ion-releasing (GIC and compomer) and resin composite restorations show no significant difference in secondary caries (RD -0.00, 95% CI -0.01 to 0.01; not GRADE-rated).

1 finding from 1 review

Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomes
Last reported follow-up (2-3 years) · Permanent dentition; university (majority), school, and private-practice settings across multiple countries (Turkey, Brazil, Sweden, India, Vietnam, Belgium, Germany, etc.)
RD -0.00 [-0.01, 0.01]
6 studies · 883 participants
GRADE not reported