Findings

What do systematic reviews say?

28 questions · 28 findings · 4 reviews

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No studies found 3 · 10.7%GRADE not reported 0 · 0%Very low 6 · 21.4%Low 5 · 17.9%Moderate 13 · 46.4%High 1 · 3.6%

Oxcarbazepine vs phenytoin

Time to first seizure (post‐randomisation) Subgroup: generalised onset seizures Range of · people with newly diagnosed epilepsy

Summary of findings: oxcarbazepine showed no clear difference in time to first seizure (post‐randomisation) Subgroup: generalised… compared with phenytoin (secondary outcomes) (low certainty).

1 finding from 1 review

Oxcarbazepine versus phenytoin monotherapy for epilepsy: an individual participant data review 2018 · Cochrane Headline outcomes only
HR 1.11 [0.66, 1.86]
2 studies · 142 participants
Low

Oxcarbazepine vs phenytoin

Remission · people with newly diagnosed epilepsy

Summary of findings: oxcarbazepine showed no clear difference in time to achieve 12‐month remission (seizure‐free period) All… compared with phenytoin (secondary outcomes) (moderate certainty).

1 finding from 1 review

Oxcarbazepine versus phenytoin monotherapy for epilepsy: an individual participant data review 2018 · Cochrane Headline outcomes only
HR 1.04 [0.77, 1.41]
2 studies · 468 participants
Moderate

RISPERIDONE vs COMBINATION: a. RISPERIDONE + OXCARBAZEPINE

Tranquillisation or asleep by 30 minutes ‐ not measured · psychosis‐induced aggression or agitation (rapid tranquillisation)

The review found no eligible studies for this question.

1 finding from 1 review

Risperidone for psychosis‐induced aggression or agitation (rapid tranquillisation) 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

RISPERIDONE vs COMBINATION: a. RISPERIDONE + OXCARBAZEPINE

Repeated need for tranquillisation ‐ not reported · psychosis‐induced aggression or agitation (rapid tranquillisation)

The review found no eligible studies for this question.

1 finding from 1 review

Risperidone for psychosis‐induced aggression or agitation (rapid tranquillisation) 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

RISPERIDONE vs COMBINATION: a. RISPERIDONE + OXCARBAZEPINE

Specific behaviour ‐ agitation · psychosis‐induced aggression or agitation (rapid tranquillisation)

1 finding from 1 review

Risperidone for psychosis‐induced aggression or agitation (rapid tranquillisation) 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 68 participants
Very low

RISPERIDONE vs COMBINATION: a. RISPERIDONE + OXCARBAZEPINE

Global Outcome: average scores, over 24 hours · psychosis‐induced aggression or agitation (rapid tranquillisation)

1 finding from 1 review

Risperidone for psychosis‐induced aggression or agitation (rapid tranquillisation) 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 68 participants
Very low

RISPERIDONE vs COMBINATION: a. RISPERIDONE + OXCARBAZEPINE

Adverse effects ‐ movement disorders · psychosis‐induced aggression or agitation (rapid tranquillisation)

It is very uncertain whether RISPERIDONE changes adverse effects: movement disorders, over 24 hours compared with COMBINATION: a. RISPERIDONE + OXCARBAZEPINE (very low certainty).

1 finding from 1 review

Risperidone for psychosis‐induced aggression or agitation (rapid tranquillisation) 2018 · Cochrane Headline outcomes only
RR 1.59 [0.49, 5.14]
1 study · 68 participants
Very low

RISPERIDONE vs COMBINATION: a. RISPERIDONE + OXCARBAZEPINE

Economic outcomes ‐ not measured · psychosis‐induced aggression or agitation (rapid tranquillisation)

The review found no eligible studies for this question.

1 finding from 1 review

Risperidone for psychosis‐induced aggression or agitation (rapid tranquillisation) 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found