What do systematic reviews say?

Calcineurin inhibitors ± oral steroids vs oral steroids alone

Calcineurin inhibitors ± oral steroids showed no clear difference in complete or partial remission time frame: 3 to 6 months compared with oral steroids alone (moderate certainty).

• Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
  RR 1.01 [0.96, 1.05]
  4 studies · 269 participants
  Moderate

Calcineurin inhibitors ± oral steroids vs oral steroids alone

Calcineurin inhibitors ± oral steroids showed no clear difference in relapse Time frame: 6 to 12 months compared with oral steroids alone (moderate certainty).

• Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
  RR 0.73 [0.51, 1.03]
  7 studies · 422 participants
  Moderate

Calcineurin inhibitors ± oral steroids vs oral steroids alone

Calcineurin inhibitors ± oral steroids showed no clear difference in adverse effects: diabetes or hyperglycaemia compared with oral steroids alone (low certainty).

• Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
  RR 0.48 [0.19, 1.25]
  7 studies · 450 participants
  Low

Calcineurin inhibitors ± oral steroids vs oral steroids alone

Calcineurin inhibitors ± oral steroids may leads to lower adverse effects: obesity or Cushing's Syndrome compared with oral steroids alone (low certainty).

• Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
  RR 0.11 [0.02, 0.59]
  5 studies · 388 participants
  Low

Calcineurin inhibitors ± oral steroids vs oral steroids alone

Calcineurin inhibitors ± oral steroids showed no clear difference in adverse effects: hypertension compared with oral steroids alone (low certainty).

• Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
  RR 0.86 [0.23, 3.2]
  3 studies · 219 participants
  Low

Calcineurin inhibitors ± oral steroids vs oral steroids alone

Calcineurin inhibitors ± oral steroids showed no clear difference in adverse events: acute kidney injury compared with oral steroids alone (low certainty).

• Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
  RR 1.78 [0.35, 8.99]
  4 studies · 270 participants
  Low

Calcineurin inhibitors ± oral steroids vs oral steroids alone

Calcineurin inhibitors ± oral steroids may leads to lower adverse effects: acne compared with oral steroids alone (low certainty).

• Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
  RR 0.15 [0.03, 0.67]
  4 studies · 270 participants
  Low

Medial epicondylectomy plus oral steroids vs oral steroids alone

• Decompressive surgery for treating nerve damage in leprosy 2012 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 57 participants
  Very low

Medial epicondylectomy plus oral steroids vs oral steroids alone

It is very uncertain whether medial epicondylectomy plus oral steroids changes proportion of ulnar nerves with sensory improvement after one year compared with oral steroids alone (very low certainty).

• Decompressive surgery for treating nerve damage in leprosy 2012 · Cochrane Headline outcomes only
  RR 1.12 [0.71, 1.77]
  1 study · 62 participants
  Very low

Medial epicondylectomy plus oral steroids vs oral steroids alone

• Decompressive surgery for treating nerve damage in leprosy 2012 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 57 participants
  Very low

Medial epicondylectomy plus oral steroids vs oral steroids alone

It is very uncertain whether medial epicondylectomy plus oral steroids changes proportion of ulnar nerves with motor improvement after one year compared with oral steroids alone (very low certainty).

• Decompressive surgery for treating nerve damage in leprosy 2012 · Cochrane Headline outcomes only
  RR 0.91 [0.64, 1.28]
  1 study · 62 participants
  Very low

Medial epicondylectomy plus oral steroids vs oral steroids alone

• Decompressive surgery for treating nerve damage in leprosy 2012 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 57 participants
  Very low

Medial epicondylectomy plus oral steroids vs oral steroids alone

• Decompressive surgery for treating nerve damage in leprosy 2012 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 57 participants
  Very low

Oral steroids vs control

Summary of findings: oral steroids showed no clear difference in hearing loss [6 weeks] compared with control (moderate certainty).

• Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children 2011 · Cochrane Headline outcomes only
  RR 1.09 [0.8, 1.49]
  1 study · 44 participants
  Moderate

Oral steroids vs control

Summary of findings: oral steroids showed no clear difference in OME resolution at short‐term compared with control (moderate certainty).

• Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children 2011 · Cochrane Headline outcomes only
  RR 3.8 [0.93, 15.52]
  3 studies · 108 participants
  Moderate

Oral steroids vs control

Summary of findings: oral steroids showed no clear difference in OME resolution at intermediate‐term compared with control (moderate certainty).

• Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children 2011 · Cochrane Headline outcomes only
  RR 1.54 [0.76, 3.14]
  3 studies · 106 participants
  Moderate

Oral steroids vs control

The review found no eligible studies for this question.

• Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children 2011 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Oral steroids vs control

The review found no eligible studies for this question.

• Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children 2011 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Oral steroids vs control

• Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children 2011 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 143 participants
  GRADE not reported

Summary of findings: oral steroids plus antibiotic vs control plus antibiotic

The review found no eligible studies for this question.

• Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children 2011 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found