Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

105 questions · 106 findings · 16 reviews · Schizophrenia

No studies found 20 · 18.9%GRADE not reported 7 · 6.6%Very low 40 · 37.7%Low 23 · 21.7%Moderate 9 · 8.5%High 7 · 6.6%

ARIPIPRAZOLE (IM) vs OLANZAPINE

Specific behaviour: Agitation ‐ clinically important change (PANSS ‐EC reduction ≥ 40% from baseline) ‐ up to 2 hours · psychosis‐induced aggression or agitation (rapid tranquillisation)

ARIPIPRAZOLE (IM) may leads to lower specific behaviour: Agitation ‐ clinically important change (PANSS… compared with OTHER ANTIPSYCHOTIC: b. OLANZAPINE (low certainty).

1 finding from 1 review

ARIPIPRAZOLE (IM) vs OLANZAPINE

Adverse effects: one or more adverse effects during 24 hours · psychosis‐induced aggression or agitation (rapid tranquillisation)

It is very uncertain whether ARIPIPRAZOLE (IM) changes adverse effects: one or more adverse effects during 24 hours compared with OTHER ANTIPSYCHOTIC: b. OLANZAPINE (very low certainty).

1 finding from 1 review

RISPERIDONE vs OLANZAPINE

Global outcome: need for additional measures · psychosis‐induced aggression or agitation (rapid tranquillisation)

It is very uncertain whether RISPERIDONE changes global outcome: need for additional measures compared with OTHER ANTIPSYCHOTIC: b. OLANZAPINE (very low certainty).

1 finding from 1 review

RISPERIDONE vs OLANZAPINE

Leaving the study early · people with both severe mental illness and substance misuse

It is very uncertain whether RISPERIDONE changes leaving study early: any reason compared with OLANZAPINE ‒ short‐ and long‐term data (very low certainty).

1 finding from 1 review