Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

67 questions · 85 findings · 7 reviews · Haematology

No studies found 17 · 20%GRADE not reported 2 · 2.4%Very low 26 · 30.6%Low 12 · 14.1%Moderate 18 · 21.2%High 10 · 11.8%

Vitamin K antagonists vs low molecular weight heparin

Major bleeding · ambulatory patients with multiple myeloma receiving immunomodulatory agents

The review found no eligible studies for this question.

2 findings from 1 review

Vitamin K antagonists vs low molecular weight heparin

Minor bleeding · ambulatory patients with multiple myeloma receiving immunomodulatory agents

It is very uncertain whether vitamin K antagonist (VKA) changes minor bleeding compared with low molecular weight heparin (LMWH) (very low certainty).

1 finding from 1 review

Aspirin vs vitamin K antagonist (VKA)

Pulmonary embolism · ambulatory patients with multiple myeloma receiving immunomodulatory agents

It is very uncertain whether aspirin (ASA) changes pulmonary embolism compared with vitamin K antagonist (VKA) (very low certainty).

2 findings from 1 review

Aspirin vs vitamin K antagonist (VKA)

Major bleeding · ambulatory patients with multiple myeloma receiving immunomodulatory agents

It is very uncertain whether aspirin (ASA) changes major bleeding compared with vitamin K antagonist (VKA) (very low certainty).

2 findings from 1 review

Intervention not reported

Overall survival## · patients with multiple myeloma

The intervention showed no clear difference in overall survival## (moderate certainty).

1 finding from 1 review

Intervention not reported

Progression‐free survival### · patients with multiple myeloma

The intervention showed no clear difference in progression‐free survival### (low certainty).

1 finding from 1 review

Intervention not reported

Non‐vertebral fractures · patients with multiple myeloma

The intervention showed no clear difference in non‐vertebral fractures (moderate certainty).

1 finding from 1 review

Intervention not reported

Skeletal‐related events · patients with multiple myeloma

The intervention probably leads to lower skeletal‐related events (moderate certainty).

1 finding from 1 review