Misoprostol vs expectant care
Diarrhoea · incomplete miscarriage
1 finding from 1 review
- no estimate extracted0 studies · 0 participantsGRADE not reported
Findings
What do systematic reviews say?
125 questions · 125 findings · 10 reviews · Pregnancy and Childbirth
No studies found 15 · 12%GRADE not reported 8 · 6.4%Very low 42 · 33.6%Low 48 · 38.4%Moderate 12 · 9.6%High 0 · 0%
Misoprostol vs surgery
Complete miscarriage · incomplete miscarriage
It is very uncertain whether misoprostol changes complete miscarriage compared with surgery (very low certainty).
1 finding from 1 review
- RR 0.96 [0.94, 0.98]15 studies · 3862 participantsVery low
Misoprostol vs surgery
Surgical evacuation · incomplete miscarriage
It is very uncertain whether misoprostol changes surgical evacuation compared with surgery (very low certainty).
1 finding from 1 review
- RR 0.05 [0.02, 0.11]13 studies · 3070 participantsVery low
Oral misoprostol one‐ to two‐hourly vs oral misoprostol four‐ to six‐hourly
Vaginal birth within 24 hours · women in the third trimester for induction of labour with intact membranes
It is very uncertain whether oral misoprostol one‐ to two‐hourly changes vaginal birth within 24 hours compared with oral misoprostol four‐ to six‐hourly (very low certainty).
1 finding from 1 review
- RR 0.6 [0.31, 1.17]1 study · 64 participantsVery low
Oral misoprostol one‐ to two‐hourly vs oral misoprostol four‐ to six‐hourly
Caesarean section · women in the third trimester for induction of labour with intact membranes
It is very uncertain whether oral misoprostol one‐ to two‐hourly changes caesarean section compared with oral misoprostol four‐ to six‐hourly (very low certainty).
1 finding from 1 review
- RR 1.31 [0.77, 2.22]1 study · 64 participantsVery low
Oral misoprostol one‐ to two‐hourly vs oral misoprostol four‐ to six‐hourly
Uterine hyperstimulation with fetal heart rate changes · women in the third trimester for induction of labour with intact membranes
1 finding from 1 review
- no estimate extracted1 study · 64 participantsVery low
Oral misoprostol one‐ to two‐hourly vs oral misoprostol four‐ to six‐hourly
Oxytocin augmentation · women in the third trimester for induction of labour with intact membranes
It is very uncertain whether oral misoprostol one‐ to two‐hourly changes oxytocin augmentation compared with oral misoprostol four‐ to six‐hourly (very low certainty).
1 finding from 1 review
- RR 1 [0.59, 1.68]1 study · 64 participantsVery low
Oral misoprostol one‐ to two‐hourly vs oral misoprostol four‐ to six‐hourly
Uterine hyperstimulation without fetal heart rate changes · women in the third trimester for induction of labour with intact membranes
It is very uncertain whether oral misoprostol one‐ to two‐hourly changes uterine hyperstimulation without fetal heart rate changes compared with oral misoprostol four‐ to six‐hourly (very low certainty).
1 finding from 1 review
- RR 4 [0.92, 17.4]1 study · 64 participantsVery low
Oral misoprostol one‐ to two‐hourly vs oral misoprostol four‐ to six‐hourly
Apgar score less than 7 at 5 minutes · women in the third trimester for induction of labour with intact membranes
1 finding from 1 review
- no estimate extracted1 study · 64 participantsVery low
Oral misoprostol one‐ to two‐hourly vs oral misoprostol four‐ to six‐hourly
Admission to neonatal intensive care unit · women in the third trimester for induction of labour with intact membranes
1 finding from 1 review
- no estimate extracted1 study · 64 participantsVery low
Oral misoprostol vs placebo/no treatment
Vaginal birth within 24 hours · women with ruptured membranes in the third trimester for induction of labour.
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Oral misoprostol vs vaginal dinoprostone
Uterine hyperstimulation with fetal heart rate changes · women in the third trimester for induction of labour.
Oral misoprostol may leads to lower uterine hyperstimulation with fetal heart rate changes compared with vaginal dinoprostone (low certainty).
1 finding from 1 review
- RR 0.49 [0.4, 0.59]11 studies · 9084 participantsLow
Oral misoprostol vs vaginal dinoprostone
Oxytocin augmentation · women in the third trimester for induction of labour.
It is very uncertain whether oral misoprostol changes oxytocin augmentation compared with vaginal dinoprostone (very low certainty).
1 finding from 1 review
- RR 0.9 [0.75, 1.09]12 studies · 9451 participantsVery low
Oral misoprostol vs vaginal dinoprostone
Uterine hyperstimulation without fetal heart rate changes · women in the third trimester for induction of labour.
Oral misoprostol probably leads to lower uterine hyperstimulation without fetal heart rate changes compared with vaginal dinoprostone (moderate certainty).
1 finding from 1 review
- RR 0.83 [0.72, 0.97]9 studies · 8171 participantsModerate
Oral misoprostol vs vaginal dinoprostone
Apgar score less than 7 at 5 minutes · women in the third trimester for induction of labour.
Oral misoprostol showed no clear difference in apgar score less than seven at five minutes compared with vaginal dinoprostone (low certainty).
1 finding from 1 review
- RR 0.8 [0.52, 1.23]12 studies · 9473 participantsLow
Oral misoprostol vs vaginal dinoprostone
Admission to neonatal intensive care unit · women in the third trimester for induction of labour.
Oral misoprostol showed no clear difference in admission to neonatal intensive care unit compared with vaginal dinoprostone (low certainty).
1 finding from 1 review
- RR 0.8 [0.6, 1.07]11 studies · 9278 participantsLow
Oral misoprostol vs placebo/no treatment
Caesarean section · women with ruptured membranes in the third trimester for induction of labour.
Oral misoprostol showed no clear difference in caesarean section compared with placebo/no treatment (low certainty).
1 finding from 1 review
- RR 0.81 [0.59, 1.11]4 studies · 594 participantsLow
Oral misoprostol vs intravenous (IV) oxytocin
Vaginal birth within 24 hours · women in the third trimester for induction of labour.
Oral misoprostol showed no clear difference in vaginal birth within 24 hours compared with intravenous oxytocin (low certainty).
1 finding from 1 review
- RR 1.12 [0.95, 1.33]3 studies · 466 participantsLow
Oral misoprostol vs intravenous (IV) oxytocin
Caesarean section · women in the third trimester for induction of labour.
Oral misoprostol probably leads to lower caesarean section compared with intravenous oxytocin (moderate certainty).
1 finding from 1 review
- RR 0.67 [0.5, 0.9]6 studies · 737 participantsModerate
Oral misoprostol vs intravenous (IV) oxytocin
Uterine hyperstimulation with fetal heart rate changes · women in the third trimester for induction of labour.
It is very uncertain whether oral misoprostol changes uterine hyperstimulation with fetal heart rate changes compared with intravenous oxytocin (very low certainty).
1 finding from 1 review
- RR 0.66 [0.19, 2.26]3 studies · 331 participantsVery low