What do systematic reviews say?

Mechanical debridement plus local antimicrobial (minocycline microspheres or doxycycline gel) vs Mechanical debridement alone

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes

  12 months
  See comment. Killeen 2016 reported no adverse events at follow-up examinations in either study arm. Tonetti 2012 reported that there were no serious adverse events.
  2 studies · 251 participants
  GRADE not reported

Mechanical debridement plus local antimicrobial (minocycline microspheres or doxycycline gel) vs Mechanical debridement alone

Mechanical debridement plus local antimicrobial (minocycline… showed no clear difference in pocket depth (mm) compared with mechanical debridement alone (low certainty).

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes

  12 months
  MD -0.10 [-0.59, 0.39]
  1 study · 51 participants
  Low

Mechanical debridement plus local antimicrobial (minocycline microspheres or doxycycline gel) vs Mechanical debridement alone

Mechanical debridement plus local antimicrobial (minocycline… showed no clear difference in clinical attachment level (mm) compared with mechanical debridement alone (low certainty).

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes

  12 months
  MD 0.10 [-0.42, 0.62]
  1 study · 53 participants
  Low

Mechanical debridement plus local antimicrobial (minocycline microspheres or doxycycline gel) vs Mechanical debridement alone

The review found no eligible studies for this question.

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes
  Not measured
  0 studies
  No studies found

Herbal medicines vs antibiotics alone

Herbal medicine showed no clear difference in secondary outcome: number of participants with remission (ITT‐best… compared with antibiotics (low certainty).

• Complementary therapies for acne vulgaris 2015 · Cochrane Headline outcomes only
  RR 2.82 [0.88, 9.06]
  2 studies · 206 participants
  Low
• Complementary therapies for acne vulgaris 2015 · Cochrane Headline outcomes only
  RR 0.49 [0.09, 2.53]
  2 studies · 206 participants
  Low

Mineral trioxide aggregate (MTA) vs 3Mix (ciprofloxacin + metronidazole + minocycline)

Mineral trioxide aggregate (MTA) may leads to lower clinical failure compared with 3Mix (ciprofloxacin + metronidazole + minocycline) (low certainty).

• Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes

  12 months
  RR 0.17 [0.04, 0.70]
  1 study · 160 participants
  Low

Vitapex (calcium hydroxide/iodoform) vs 3Mix (ciprofloxacin + metronidazole + minocycline)

Vitapex (calcium hydroxide/iodoform) showed no clear difference in radiological failure compared with 3Mix (ciprofloxacin + metronidazole + minocycline); GRADE not reported.

• Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes

  12 months
  RR 1.83 [0.80, 4.19]
  1 study · 50 participants
  GRADE not reported

Vitapex (calcium hydroxide/iodoform) vs 3Mix (ciprofloxacin + metronidazole + minocycline)

Vitapex (calcium hydroxide/iodoform) showed no clear difference in clinical failure compared with 3Mix (ciprofloxacin + metronidazole + minocycline); GRADE not reported.

• Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes

  12 months
  RR 1.00 [0.07, 15.12]
  1 study · 50 participants
  GRADE not reported

Mineral trioxide aggregate (MTA) vs 3Mix (ciprofloxacin + metronidazole + minocycline)

• Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes

  12 months
  No radiological failure in any participant (Aminabadi 2016); not estimable
  1 study · 160 participants
  GRADE not reported