Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

38 questions · 38 findings · 4 reviews · Headline outcomes only

No studies found 6 · 15.8%GRADE not reported 0 · 0%Very low 10 · 26.3%Low 13 · 34.2%Moderate 7 · 18.4%High 2 · 5.3%

Summary of findings table ‐ Off‐midline closure (Karydakis flap) vs off‐midline closure (Limberg flap)

Recurrence · pilonidal sinus

Summary of findings table ‐ Off‐midline closure (Karydakis flap) showed no clear difference in recurrence rate compared with off‐midline closure (Limberg flap) (low certainty).

1 finding from 1 review

Summary of findings table ‐ Off‐midline closure (Karydakis flap) vs off‐midline closure (Limberg flap)

Wound infection · pilonidal sinus

Summary of findings table ‐ Off‐midline closure (Karydakis flap) showed no clear difference in wound infection compared with off‐midline closure (Limberg flap) (low certainty).

1 finding from 1 review

Summary of findings table ‐ Off‐midline closure (Karydakis flap) vs off‐midline closure (Limberg flap)

Wound dehiscence · pilonidal sinus

Summary of findings table ‐ Off‐midline closure (Karydakis flap) showed no clear difference in wound dehiscence compared with off‐midline closure (Limberg flap) (low certainty).

1 finding from 1 review

Supine midline head position vs any other supine head position

Intraventricular haemorrhage · very preterm infants with or at risk of germinal matrix‐intraventricular haemorrhage in preterm infants

It is very uncertain whether supine midline head position changes intraventricular haemorrhage, any grade compared with any other supine head position (very low certainty).

1 finding from 1 review

Supine midline head position vs any other supine head position

Intraventricular haemorrhage, Papile grade 3/4 · very preterm infants with or at risk of germinal matrix‐intraventricular haemorrhage in preterm infants

It is very uncertain whether supine midline head position changes intraventricular haemorrhage, grade 3 to 4 compared with any other supine head position (very low certainty).

1 finding from 1 review

Supine midline head position vs any other supine head position

All‐cause mortality during hospital stay · very preterm infants with or at risk of germinal matrix‐intraventricular haemorrhage in preterm infants

It is very uncertain whether supine midline head position changes mortality during initial hospitalisation compared with any other supine head position (very low certainty).

1 finding from 1 review

Supine midline head position vs any other supine head position

Retinopathy of prematurity, > stage 3 · very preterm infants with or at risk of germinal matrix‐intraventricular haemorrhage in preterm infants

It is very uncertain whether supine midline head position changes retinopathy of prematurity, > stage 3 compared with any other supine head position (very low certainty).

1 finding from 1 review

Supine midline head position vs any other supine head position

Long‐term neurodevelopmental outcome ‒not reported · very preterm infants with or at risk of germinal matrix‐intraventricular haemorrhage in preterm infants

The review found no eligible studies for this question.

1 finding from 1 review

Supine midline head position vs any other supine head position

Major neurodevelopmental disability ‒not reported · very preterm infants with or at risk of germinal matrix‐intraventricular haemorrhage in preterm infants

The review found no eligible studies for this question.

1 finding from 1 review

Supine midline head position vs any other supine head position

Cerebellar haemorrhage on brain ultrasound ‐ not reported · very preterm infants with or at risk of germinal matrix‐intraventricular haemorrhage in preterm infants

The review found no eligible studies for this question.

1 finding from 1 review

Continuous local anaesthetic wound infusion vs placebo

Any serious postoperative adverse event (until hospital discharge) · adults undergoing elective midline laparotomy for colorectal resection

Continuous local anaesthetic wound infusion showed no clear difference in any serious postoperative adverse event (until hospital discharge) compared with placebo (low certainty).

1 finding from 1 review