Ovulation rate per woman fParticipants with BMI ≥ 30 kg/m2 · women with polycystic ovary syndrome
Metformin may leads to lower ovulation rate per woman fParticipants with BMI ≥ 30 kg/m2 compared with clomiphene citrate (low certainty).
Change in eGFR · preventing the progression of CKD
1 finding from 1 review
Serious adverse events ( · preventing the progression of CKD
Metformin showed no clear difference in serious adverse events ( compared with active control (moderate certainty).
1 finding from 1 review
Withdrew due to intolerance ( · preventing the progression of CKD
Metformin showed no clear difference in withdrew due to intolerance ( compared with active control (moderate certainty).
1 finding from 1 review
Dosing and tolerance ( · preventing the progression of CKD
1 finding from 1 review
Kidney failure · preventing the progression of CKD
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
UACR (% change) ( · preventing the progression of CKD
1 finding from 1 review
All‐cause death ( · preventing the progression of CKD
It is very uncertain whether metformin changes all‐cause death ( compared with placebo (very low certainty).
1 finding from 1 review
Serious adverse events ( · preventing the progression of CKD
Metformin showed no clear difference in serious adverse events ( compared with placebo (moderate certainty).
1 finding from 1 review
Withdrew due to intolerance ( · preventing the progression of CKD
Metformin probably leads to higher withdrew due to intolerance ( compared with placebo (moderate certainty).
1 finding from 1 review
Dose tolerability ( · preventing the progression of CKD
1 finding from 1 review
Kidney failure · preventing the progression of CKD
It is very uncertain whether metformin changes kidney failure (median compared with placebo (very low certainty).
1 finding from 1 review
Change in proteinuria (1 year) · preventing the progression of CKD
1 finding from 1 review
Change in eGFR · preventing the progression of CKD
1 finding from 1 review
All‐cause death ( · preventing the progression of CKD
Metformin showed no clear difference in all‐cause death ( compared with active control (low certainty).
1 finding from 1 review
Hirsutism ‐ Clinical F‐G score · adult women with PCOS
1 finding from 1 review
Hirsutism ‐ Clinical F‐G score · adolescent women with PCOS
1 finding from 1 review
Adverse events ‐ Severe · adult women with PCOS
Metformin may leads to higher adverse events ‐ Severe compared with oral contraceptive pill (OCP) (low certainty).
1 finding from 1 review
Adverse event ‐ Severe · adolescent women with PCOS
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Minor adverse events · adolescent women with PCOS
It is very uncertain whether metformin changes adverse event ‐ Minor compared with oral contraceptive pill (OCP) (very low certainty).
1 finding from 1 review