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Evidence found and GRADE certainty

29 questions · 31 findings · 2 reviews · Dementia and Cognitive Improvement

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No studies found 2 · 6.5%GRADE not reported 0 · 0%Very low 2 · 6.5%Low 13 · 41.9%Moderate 6 · 19.4%High 8 · 25.8%

Intervention not reported

Number suffering agitation as an adverse event · vascular dementia, mild‐to‐moderate severity
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 900 participants
    Low

Intervention not reported

Cognitive Function (SIB) · Alzheimer's disease (AD), moderate‐to‐severe
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    13 studies · 3337 participants
    High

Intervention not reported

Functional performance on activities of daily living: ADCS‐ADL19 54‐point scale · Alzheimer's disease (AD), moderate‐to‐severe
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    11 studies · 2687 participants
    High

Intervention not reported

Behaviour and Mood (NPI) · Alzheimer's disease (AD), moderate‐to‐severe
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    14 studies · 3674 participants
    High

Intervention not reported

Binary outcomes · Alzheimer's disease (AD), moderate‐to‐severe

The review found no eligible studies for this question.

1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Intervention not reported

All‐cause discontinuation · Alzheimer's disease (AD), moderate‐to‐severe
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    17 studies · 5087 participants
    High

Intervention not reported

Number suffering at least one adverse event · Alzheimer's disease (AD), moderate‐to‐severe
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    29 studies · 8033 participants
    High

Intervention not reported

Number suffering at least one serious adverse event · Alzheimer's disease (AD), moderate‐to‐severe
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    19 studies · 6482 participants
    High

Intervention not reported

Number suffering agitation as an adverse event · Alzheimer's disease (AD), moderate‐to‐severe
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    12 studies · 4395 participants
    Moderate