Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

47 questions · 52 findings · 5 reviews

No studies found 5 · 9.6%GRADE not reported 0 · 0%Very low 7 · 13.5%Low 26 · 50%Moderate 6 · 11.5%High 8 · 15.4%

Discontinuing cholinesterase inhibitor vs continued cholinesterase inhibitor

Change in NPI · people with dementia
2 findings from 1 review

Intervention not reported

Clinical Global (CIBIC+) · Alzheimer's disease (AD), moderate‐to‐severe
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    10 studies · 2797 participants
    High

Intervention not reported

Clinical Global: (CIBIC+) · vascular dementia, mild‐to‐moderate severity
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 757 participants
    Moderate

Intervention not reported

Cognitive function: ADAS‐Cog 70‐point scale · vascular dementia, mild‐to‐moderate severity
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 569 participants
    Moderate

Intervention not reported

Performance on ADL (NOSGER self care subscale) Subscale 5 points · vascular dementia, mild‐to‐moderate severity
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 542 participants
    Low

Intervention not reported

Behaviour: NOSGER disturbing behaviour subscale Subscale 5 points · vascular dementia, mild‐to‐moderate severity
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 542 participants
    Low

Intervention not reported

Binary outcomes · vascular dementia, mild‐to‐moderate severity

The review found no eligible studies for this question.

1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Intervention not reported

All‐cause discontinuation · vascular dementia, mild‐to‐moderate severity
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 900 participants
    Low

Intervention not reported

Number suffering at least one adverse event · vascular dementia, mild‐to‐moderate severity
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    29 studies · 8033 participants
    High

Intervention not reported

Number suffering at least one serious adverse event · vascular dementia, mild‐to‐moderate severity
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 900 participants
    Low

Intervention not reported

Number suffering agitation as an adverse event · vascular dementia, mild‐to‐moderate severity
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 900 participants
    Low

Intervention not reported

Cognitive Function (SIB) · Alzheimer's disease (AD), moderate‐to‐severe
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    13 studies · 3337 participants
    High