Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

107 questions · 107 findings · 25 reviews · Eyes and Vision

No studies found 35 · 32.7%GRADE not reported 1 · 0.9%Very low 17 · 15.9%Low 25 · 23.4%Moderate 27 · 25.2%High 2 · 1.9%

Any intervention vs steroid alone or plus levofloxacin

Proportion of participants who discontinued medication and did not develop rebound SEI within 21 days (higher is favored) · epidemic keratoconjunctivitis

It is very uncertain whether any intervention changes proportion of participants who discontinued medication and did not… compared with steroid alone or plus levofloxacin (very low certainty).

1 finding from 1 review

Methotrexate vs mycophenolate

Proportion of participants experiencing complications or requiring cessation of medication (lower number of events is better) · NIIPPU

Methotrexate showed no clear difference in proportion of participants experiencing complications or requiring… compared with mycophenolate (low certainty).

1 finding from 1 review

Steroids with or without azathioprine vs cyclosporine A

Proportion of participants experiencing complications or requiring cessation of medication (lower number of events is better) · NIIPPU

It is very uncertain whether steroids with or without azathioprine changes proportion of participants experiencing complications or requiring… compared with cyclosporine A (very low certainty).

1 finding from 1 review

Intervention not reported

Additional medications required · adults with PACS or PAC, and previous PI

The review found no eligible studies for this question.

1 finding from 1 review