Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

155 questions · 157 findings · 22 reviews · Heart

No studies found 6 · 3.8%GRADE not reported 7 · 4.5%Very low 23 · 14.6%Low 60 · 38.2%Moderate 44 · 28%High 17 · 10.8%

ICD plus optimal medical therapy vs optimal medical therapy alone

All‐cause mortality (HR) ‐ main analysisa 16.5 to 67.6 months · DCM (non‐ischaemic)

ICD plus optimal medical therapy leads to lower all‐cause mortality (HR) ‐ main analysisa 16.5 to 67.6 months compared with optimal medical therapy alone (high certainty).

1 finding from 1 review

ICD plus optimal medical therapy vs optimal medical therapy alone

Noncardiovascular mortality (RR)b 22.8 to 67.6 months · DCM (non‐ischaemic)

ICD plus optimal medical therapy showed no clear difference in noncardiovascular mortality (RR)b 22.8 to 67.6 months compared with optimal medical therapy alone (moderate certainty).

1 finding from 1 review

Herbal medicines vs supportive therapy

Number of patients died of cardiac failure ‐ Astragaloside injection versus support therapy · patients with viral myocarditis

It is very uncertain whether herbal medicines changes number of patients died of cardiac failure: Astragaloside injection… compared with supportive therapy (very low certainty).

1 finding from 1 review

Herbal medicines vs supportive therapy

Number of patients with premature beat ‐ Xinshu Capsule versus supportive therapy · patients with viral myocarditis

It is very uncertain whether herbal medicines changes number of patients with premature beat: Xinshu capsule versus… compared with supportive therapy (very low certainty).

1 finding from 1 review

Ranolazine (monotherapy) vs placebo

All‐cause mortality · patients with stable angina pectoris

Ranolazine (monotherapy) showed no clear difference in all‐cause mortality compared with placebo (low certainty).

1 finding from 1 review