Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

259 questions · 260 findings · 27 reviews · Airways

No studies found 22 · 8.5%GRADE not reported 15 · 5.8%Very low 30 · 11.5%Low 99 · 38.1%Moderate 79 · 30.4%High 15 · 5.8%

Oral + inhaled dual therapy vs oral monotherapy

Successful treatment of exacerbation: number of participants cured. Outcome assessed on day 42 · bronchiectasis

It is very uncertain whether oral + inhaled dual therapy changes successful treatment of exacerbation: number of participants cured.… compared with oral monotherapy (very low certainty).

1 finding from 1 review

Oral + inhaled dual therapy vs oral monotherapy

Successful treatment of exacerbation: number of participants with P aeruginosa eradication. Outcome assessed on day 21 · bronchiectasis

It is very uncertain whether oral + inhaled dual therapy changes successful treatment of exacerbation: number of participants with P… compared with oral monotherapy (very low certainty).

1 finding from 1 review

Oral + inhaled dual therapy vs oral monotherapy

Serious adverse events. Outcome assessed on day 42 · bronchiectasis

It is very uncertain whether oral + inhaled dual therapy changes serious adverse events. Outcome assessed on day 42 compared with oral monotherapy (very low certainty).

1 finding from 1 review

Oral + inhaled dual therapy vs oral monotherapy

Microbiological response: eradicated. Outcome assessed on day 21 · bronchiectasis

It is very uncertain whether oral + inhaled dual therapy changes microbiological response: eradicated. Outcome assessed on day 21 compared with oral monotherapy (very low certainty).

1 finding from 1 review