Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,808 questions · 8,953 findings · 827 reviews · Headline outcomes only

No studies found 1,891 · 21.1%GRADE not reported 380 · 4.2%Very low 2,100 · 23.5%Low 2,449 · 27.4%Moderate 1,684 · 18.8%High 449 · 5%

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Bright white light therapy vs infrared light therapy

Overall discontinuation ( · All participants were known SAD patients who had been successfully treated with conventional light therapy in previous winters

It is very uncertain whether bright white light therapy changes overall discontinuation ( compared with infrared light therapy (very low certainty).

1 finding from 1 review

Bright white light therapy vs no light therapy

Incidence of severe SAD (SIGH‐SAD‐SR (≥ 40)) ( · All participants were known SAD patients who had been successfully treated with conventional light therapy in previous winters

It is very uncertain whether bright white light therapy changes incidence of severe SAD (SIGH‐SAD‐SR (≥ 40)) ( compared with no light therapy (very low certainty).

1 finding from 1 review

Bright white light therapy vs no light therapy

Overall discontinuation ( · All participants were known SAD patients who had been successfully treated with conventional light therapy in previous winters

It is very uncertain whether bright white light therapy changes overall discontinuation ( compared with no light therapy (very low certainty).

1 finding from 1 review

Schema therapy vs usual care

Adverse events Assessed by: number of participants with a global negative outcome (e.g. dropping out of therapy, recidivism or being transferred to another facility due to poor treatment response) overall Timing of assessment: over the 3 years · adults with antisocial personality disorder

The review found no eligible studies for this question.

1 finding from 1 review

GnRH agonist plus chemotherapy vs chemotherapy alone

Menstruation recovery or maintenance: · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

GnRH agonist plus chemotherapy may leads to higher menstruation recovery or maintenance: compared with chemotherapy alone (low certainty).

2 findings from 1 review

GnRH agonist plus chemotherapy vs chemotherapy alone

Premature ovarian failure · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

GnRH agonist plus chemotherapy probably leads to lower premature ovarian failure compared with chemotherapy alone (moderate certainty).

1 finding from 1 review

GnRH agonist plus chemotherapy vs chemotherapy alone

Pregnancy · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

GnRH agonist plus chemotherapy showed no clear difference in pregnancy compared with chemotherapy alone (low certainty).

1 finding from 1 review

GnRH agonist plus chemotherapy vs chemotherapy alone

Ovulation · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

GnRH agonist plus chemotherapy may leads to higher ovulation compared with chemotherapy alone (low certainty).

1 finding from 1 review

GnRH agonist plus chemotherapy vs chemotherapy alone

Adverse effects: hot flush · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

It is very uncertain whether gnRH agonist plus chemotherapy changes adverse effects: hot flush compared with chemotherapy alone (very low certainty).

1 finding from 1 review

GnRH agonist plus chemotherapy vs chemotherapy alone

Adverse effects: vaginal dryness · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

GnRH agonist plus chemotherapy showed no clear difference in adverse effects: vaginal dryness compared with chemotherapy alone (moderate certainty).

1 finding from 1 review

Platinum‐containing chemotherapy vs chemotherapy without platinum

Disease-free survival · neoadjuvant therapy for early triple‐negative breast cancer

Platinum‐containing chemotherapy leads to lower DFS at 2 years compared with chemotherapy without platinum (high certainty).

2 findings from 1 review

Platinum‐containing chemotherapy vs chemotherapy without platinum

Disease-free survival · early triple‐negative breast cancer

Platinum‐containing chemotherapy leads to lower DFS at 2 years compared with chemotherapy without platinum (high certainty).

2 findings from 1 review