Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

460 questions · 464 findings · 50 reviews · Pregnancy and Childbirth

No studies found 103 · 22.2%GRADE not reported 61 · 13.1%Very low 120 · 25.9%Low 112 · 24.1%Moderate 59 · 12.7%High 9 · 1.9%

Dexamethasone vs betamethasone – child outcomes

Intellectual impairment: developmental delay – cognitive or language (mild, moderate or severe) · women at risk of preterm birth

Dexamethasone showed no clear difference in intellectual impairment: developmental delay – cognitive or language… compared with betamethasone – child outcomes (moderate certainty).

1 finding from 1 review

Dexamethasone vs betamethasone – maternal outcomes

Maternal adverse effects of therapy · women at risk of preterm birth

Dexamethasone showed no clear difference in maternal adverse effects of therapy compared with betamethasone – maternal outcomes (moderate certainty).

1 finding from 1 review

Dexamethasone vs betamethasone – child outcomes

Any known death after randomisation (fetal, neonatal, child, child as adult) · women at risk of preterm birth

Dexamethasone showed no clear difference in any known death after randomisation (fetal, neonatal, child, child… compared with betamethasone – fetal/neonatal outcomes (moderate certainty).

1 finding from 1 review

Metoclopramide vs promethazine

Intervention side effects: unable to sleep · Pregnant women with hyperemesis gravidarum

Metoclopramide showed no clear difference in intervention side effects: unable to sleep compared with promethazine (low certainty).

1 finding from 1 review

Metoclopramide vs promethazine

Frequency of adverse effects ‐ dizziness ( · Pregnant women with hyperemesis gravidarum

Metoclopramide probably leads to lower intervention side effects: felt dizzy compared with promethazine (moderate certainty).

1 finding from 1 review

Metoclopramide vs promethazine

Gastrointestinal side effects (diarrhoea) ‐ not reported · Pregnant women with hyperemesis gravidarum

Metoclopramide showed no clear difference in intervention side effects: diarrhea compared with promethazine (low certainty).

1 finding from 1 review

Metoclopramide vs promethazine

Severity, reduction or cessation in nausea/vomiting 2. Number of episodes of emesis 3. Days of hospital admission 4. Pregnancy complications 5. Adverse fetal/neonatal outcomes · Pregnant women with hyperemesis gravidarum

The review found no eligible studies for this question.

1 finding from 1 review