Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

479 questions · 502 findings · 35 reviews · Effective Practice and Organisation of Care

No studies found 140 · 27.9%GRADE not reported 24 · 4.8%Very low 139 · 27.7%Low 137 · 27.3%Moderate 51 · 10.2%High 11 · 2.2%

Primary health professional‐led psychological interventions vs usual care or no treatment

Anxiety and depression · adults with post‐traumatic stress or common mental disorders

Primary health professional‐led psychological interventions may leads to higher prevalence of adults with probable depression or anxiety (1 to 6… compared with usual or no care (low certainty).

1 finding from 1 review

Lay health worker‐led interventions for adult patients with harmful or hazardous alcohol or substance use vs enhanced usual care

Prevalence of methamphetamine use (1 to 6 months post intervention) (RR < 1 denotes lower prevalence compared to control) · adult patients with harmful or hazardous alcohol or substance use

Lay health worker‐led interventions for adult patients with harmful… showed no clear difference in prevalence of methamphetamine use (1 to 6 months post intervention)… compared with enhanced usual care (low certainty).

1 finding from 1 review

Lay health worker‐led interventions for adult patients with harmful or hazardous alcohol or substance use vs enhanced usual care

Service utilisation ‐ unplanned hospitalisations (1 to 6 months post intervention) (RR < 1 denotes lower risk) · adult patients with harmful or hazardous alcohol or substance use

It is very uncertain whether lay health worker‐led interventions for adult patients with harmful… changes service utilisation ‐ unplanned hospitalisations (1 to 6 months post… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐led interventions for adult patients with harmful or hazardous alcohol or substance use vs enhanced usual care

Adverse events ‐ death in past 12 months (RR > 1 denotes higher risk of death) · adult patients with harmful or hazardous alcohol or substance use

It is very uncertain whether lay health worker‐led interventions for adult patients with harmful… changes adverse events ‐ deaths (RR < 1 denotes lower risk) compared with enhanced usual care (very low certainty).

1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Cannabis use · adult patients with harmful or hazardous alcohol or substance use

It is very uncertain whether primary health professional‐ and community professional‐led… changes prevalence of cannabis use (1 to 6 months post intervention) (RR < 1… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐led psychological interventions vs usual care

Adverse events RR < 1 indicates lower risk of adverse events · adults with common mental disorders

Lay health worker‐led psychological interventions may leads to lower adverse events RR < 1 indicates lower risk of adverse events compared with usual care (low certainty).

1 finding from 1 review

Primary‐level worker‐led collaborative care vs usual care

Prevalence of CMD ‐ intermediate term (1 to 6 months post intervention) Diagnosis defined by presence of ICD‐10 diagnosis on CIS‐Rg; prevalence defined by [Total number ‐ number recovered (recovery defined by HDRS < 8)]c (RR < 1 denotes lower prev... · adults with common mental disorders

Primary‐level worker‐led collaborative care showed no clear difference in prevalence of CMD ‐ intermediate term (1 to 6 months post… compared with usual care (low certainty).

1 finding from 1 review

Non‐specialist‐led vs specialist‐led follow‐up after primary cancer treatment

Overall survival · adult cancer survivors from the following cancer sites: breast, colon, colorectal, endometrial, ovarian, cervical, melanoma and oesophageal

It is very uncertain whether non‐specialist‐led changes overall survival compared with specialist‐led follow‐up after primary cancer treatment (very low certainty).

1 finding from 1 review

Less intensive vs more intensive follow‐up after primary cancer treatment

Depression · adult cancer survivors from the following cancer sites: breast, colorectal, head‐and‐neck, Hodgkin lymphoma, melanoma, non‐small cell lung…

The review found no eligible studies for this question.

1 finding from 1 review

Non‐specialist‐led vs specialist‐led follow‐up after primary cancer treatment

Health‐related quality of life, (at 12 months' · adult cancer survivors from the following cancer sites: breast, colon, colorectal, endometrial, ovarian, cervical, melanoma and oesophageal

Non‐specialist‐led showed no clear difference in health‐related quality of life, (at 12 months' compared with specialist‐led follow‐up after primary cancer treatment (low certainty).

1 finding from 1 review

Non‐specialist‐led vs specialist‐led follow‐up after primary cancer treatment

Anxiety · adult cancer survivors from the following cancer sites: breast, colon, colorectal, endometrial, ovarian, cervical, melanoma and oesophageal

Non‐specialist‐led showed no clear difference in anxiety (at 12 months' compared with specialist‐led follow‐up after primary cancer treatment (moderate certainty).

1 finding from 1 review

Non‐specialist‐led vs specialist‐led follow‐up after primary cancer treatment

Depressive symptoms · adult cancer survivors from the following cancer sites: breast, colon, colorectal, endometrial, ovarian, cervical, melanoma and oesophageal

Non‐specialist‐led showed no clear difference in depression (at 12 months) HADS‐Depression subscale (higher scores… compared with specialist‐led follow‐up after primary cancer treatment (high certainty).

1 finding from 1 review

Less intensive vs more intensive follow‐up after primary cancer treatment

Overall survival · adult cancer survivors from the following cancer sites: breast, colorectal, head‐and‐neck, Hodgkin lymphoma, melanoma, non‐small cell lung…

Less intensive showed no clear difference in overall survival compared with more intensive follow‐up after primary cancer treatment (low certainty).

1 finding from 1 review

Less intensive vs more intensive follow‐up after primary cancer treatment

Time to detection of recurrence · adult cancer survivors from the following cancer sites: breast, colorectal, head‐and‐neck, Hodgkin lymphoma, melanoma, non‐small cell lung…

Less intensive probably leads to lower time to detection of recurrence compared with more intensive follow‐up after primary cancer treatment (moderate certainty).

1 finding from 1 review