28‐Day all cause mortality (adult studies) · adult patients with sepsis, severe sepsis and septic shock
Polyclonal intravenous immunoglobulin (IVIG) showed no clear difference in low risk of bias adult studies, by type of polyclonal IVIG,… compared with placebo or no intervention (high certainty).
3 findings from 1 review
RR 0.97 [0.81, 1.15]
5 studies · 945 participants
High
RR 1.02 [0.84, 1.24]
3 studies · 683 participants
High
RR 0.82 [0.56, 1.19]
2 studies · 262 participants
Moderate
All‐cause mortality: range 1 mo to 1 y · adults admitted to the ICU
It is very uncertain whether higher changes all‐cause mortality: range 1 mo to 1 y compared with lower FiO2 or targets of arterial oxygenation (very low certainty).
1 finding from 1 review
Proportion of participants with 1 or more serious adverse events according to International Conference on Harmonisation Good Clinical Practice (ICH‐GCP) · adults admitted to the ICU
It is very uncertain whether higher changes proportion of participants with ≥ 1 serious adverse events according… compared with lower FiO2 or targets of arterial oxygenation (very low certainty).
1 finding from 1 review
Quality of life (any measure): range 180 d to 1 y · adults admitted to the ICU
1 finding from 1 review
Lung injury diagnosed after randomisation (composite outcome): range 4 d to 23 d · adults admitted to the ICU
It is very uncertain whether higher changes lung injury diagnosed after randomisation (composite outcome): range… compared with lower FiO2 or targets of arterial oxygenation (very low certainty).
1 finding from 1 review
Myocardial infarction · adults admitted to the ICU
It is very uncertain whether higher changes myocardial infarction diagnosed after randomisation: range ≤ 90 d compared with lower FiO2 or targets of arterial oxygenation (very low certainty).
1 finding from 1 review
Stroke · adults admitted to the ICU
It is very uncertain whether higher changes stroke diagnosed after randomisation: range 1 mo to 3 mo compared with lower FiO2 or targets of arterial oxygenation (very low certainty).
1 finding from 1 review
Sepsis diagnosed after randomisation: range 28 d to 60 d · adults admitted to the ICU
It is very uncertain whether higher changes sepsis diagnosed after randomisation: range 28 d to 60 d compared with lower FiO2 or targets of arterial oxygenation (very low certainty).
1 finding from 1 review
Mortality before hospital discharge · patients with ALI and ARDS
High levels of PEEP showed no clear difference in mortality before hospital discharge compared with low levels of PEEP (moderate certainty).
1 finding from 1 review
Oxygen efficiency (PaO2/FiO2) day 1 postoperative · patients with ALI and ARDS
1 finding from 1 review
Oxygen efficiency (PaO2/FiO2) day 3 postoperative · patients with ALI and ARDS
1 finding from 1 review
Oxygen efficiency (PaO2/FIO2). Day 7 · patients with ALI and ARDS
1 finding from 1 review
Barotrauma · patients with ALI and ARDS
High levels of PEEP showed no clear difference in barotrauma compared with low levels of PEEP (low certainty).
1 finding from 1 review
Ventilator‐free days up to day 28 · patients with ALI and ARDS
1 finding from 1 review
All‐cause mortality · people hospitalised with COVID‐19
Higher‐dose anticoagulants showed no clear difference in all‐cause mortality compared with lower‐dose anticoagulants (high certainty).
1 finding from 1 review
Necessity for additional respiratory support · people hospitalised with COVID‐19
It is very uncertain whether higher‐dose anticoagulants changes necessity for additional respiratory support compared with lower‐dose anticoagulants (very low certainty).
1 finding from 1 review
Mortality related to COVID‐19 · people hospitalised with COVID‐19
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Deep vein thrombosis · people hospitalised with COVID‐19
Higher‐dose anticoagulants showed no clear difference in deep vein thrombosis compared with lower‐dose anticoagulants (low certainty).
1 finding from 1 review
Pulmonary embolism · people hospitalised with COVID‐19
Higher‐dose anticoagulants probably leads to lower pulmonary embolism compared with lower‐dose anticoagulants (moderate certainty).
1 finding from 1 review
Major bleeding · people hospitalised with COVID‐19
Higher‐dose anticoagulants probably leads to higher major bleeding compared with lower‐dose anticoagulants (moderate certainty).
1 finding from 1 review