Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

71 questions · 71 findings · 8 reviews

No studies found 16 · 22.5%GRADE not reported 0 · 0%Very low 33 · 46.5%Low 14 · 19.7%Moderate 7 · 9.9%High 1 · 1.4%

Levetiracetam vs placebo

Leaving the study early · patients with antipsychotic‐induced tardive dyskinesia

It is very uncertain whether ANTIEPILEPTIC ‐ LEVETIRACETAM changes acceptability of treatment (measured by participants leaving the… compared with PLACEBO (very low certainty).

1 finding from 1 review

Levetiracetam vs placebo

Withdrawals due to adverse events · adults with SAnD

It is very uncertain whether comparison 3: anticonvulsant levetiracetam changes dropouts due to adverse events (acute phase) compared with placebo (very low certainty).

1 finding from 1 review

Levetiracetam vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults with SAnD

Comparison 3: anticonvulsant levetiracetam showed no clear difference in global Impressions scale change item (CGI‐I or similar): no. of… compared with placebo (moderate certainty).

1 finding from 1 review

Phenobarbital vs levetiracetam

Proportion of infants who achieve seizure control after the first loading dose of ASM · neonates with EEG‐confirmed seizures

Summary of findings table ‐ Phenobarbital probably leads to higher proportion of infants who achieve seizure control after the first… compared with levetiracetam (moderate certainty).

1 finding from 1 review