Findings

What do systematic reviews say?

47 questions · 47 findings · 9 reviews · Oral and maxillofacial surgery

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No studies found 14 · 29.8%GRADE not reported 27 · 57.4%Very low 6 · 12.8%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Pre-radiotherapy extraction of healthy molar teeth vs Conservative treatment (leaving the teeth in place during radiotherapy, with oral health education and disease prevention: oral hygiene, fluoride, diet advice)

Overall survival · Patients diagnosed with head and neck cancer planned to undergo any type of radiotherapy (external beam, intensity modulated,…

The review found no eligible studies for this question.

1 finding from 1 review

Dental extractions prior to radiotherapy to the jaws for reducing post‐radiotherapy dental complications 2013 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Pre-radiotherapy extraction of diseased molar teeth vs Conservative treatment (restoration of the teeth and leaving them in place during radiotherapy, with oral health education and disease prevention: oral hygiene, fluoride, diet advice)

Trismus preventing further restorative treatment · Patients diagnosed with head and neck cancer planned to undergo any type of radiotherapy (external beam, intensity modulated,…

The review found no eligible studies for this question.

1 finding from 1 review

Dental extractions prior to radiotherapy to the jaws for reducing post‐radiotherapy dental complications 2013 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Pre-radiotherapy extraction of healthy molar teeth vs Conservative treatment (leaving the teeth in place during radiotherapy, with oral health education and disease prevention: oral hygiene, fluoride, diet advice)

Trismus preventing further restorative treatment · Patients diagnosed with head and neck cancer planned to undergo any type of radiotherapy (external beam, intensity modulated,…

The review found no eligible studies for this question.

1 finding from 1 review

Dental extractions prior to radiotherapy to the jaws for reducing post‐radiotherapy dental complications 2013 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Pre-radiotherapy extraction of diseased molar teeth vs Conservative treatment (restoration of the teeth and leaving them in place during radiotherapy, with oral health education and disease prevention: oral hygiene, fluoride, diet advice)

Development of post-radiotherapy dental complications (caries, fractured teeth, periapical infection, periodontal disease, osteoradionecrosis) · Patients diagnosed with head and neck cancer planned to undergo any type of radiotherapy (external beam, intensity modulated,…

The review found no eligible studies for this question.

1 finding from 1 review

Dental extractions prior to radiotherapy to the jaws for reducing post‐radiotherapy dental complications 2013 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Pre-radiotherapy extraction of diseased molar teeth vs Conservative treatment (restoration of the teeth and leaving them in place during radiotherapy, with oral health education and disease prevention: oral hygiene, fluoride, diet advice)

Delay in start of radiation treatment · Patients diagnosed with head and neck cancer planned to undergo any type of radiotherapy (external beam, intensity modulated,…

The review found no eligible studies for this question.

1 finding from 1 review

Dental extractions prior to radiotherapy to the jaws for reducing post‐radiotherapy dental complications 2013 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Pre-radiotherapy dental extraction vs Post-radiotherapy dental extraction

Outcome not reported · Patients diagnosed with head and neck cancer planned to undergo any type of radiotherapy (external beam, intensity modulated,…

The review found no eligible studies for this question.

1 finding from 1 review

Dental extractions prior to radiotherapy to the jaws for reducing post‐radiotherapy dental complications 2013 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Pre-radiotherapy extraction of healthy molar teeth vs Conservative treatment (leaving the teeth in place during radiotherapy, with oral health education and disease prevention: oral hygiene, fluoride, diet advice)

Patients' quality of life · Patients diagnosed with head and neck cancer planned to undergo any type of radiotherapy (external beam, intensity modulated,…

The review found no eligible studies for this question.

1 finding from 1 review

Dental extractions prior to radiotherapy to the jaws for reducing post‐radiotherapy dental complications 2013 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Pre-radiotherapy extraction of diseased molar teeth vs Conservative treatment (restoration of the teeth and leaving them in place during radiotherapy, with oral health education and disease prevention: oral hygiene, fluoride, diet advice)

Patients' quality of life · Patients diagnosed with head and neck cancer planned to undergo any type of radiotherapy (external beam, intensity modulated,…

The review found no eligible studies for this question.

1 finding from 1 review

Dental extractions prior to radiotherapy to the jaws for reducing post‐radiotherapy dental complications 2013 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Pre-radiotherapy extraction of diseased molar teeth vs Conservative treatment (restoration of the teeth and leaving them in place during radiotherapy, with oral health education and disease prevention: oral hygiene, fluoride, diet advice)

Overall survival · Patients diagnosed with head and neck cancer planned to undergo any type of radiotherapy (external beam, intensity modulated,…

The review found no eligible studies for this question.

1 finding from 1 review

Dental extractions prior to radiotherapy to the jaws for reducing post‐radiotherapy dental complications 2013 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Pre-radiotherapy extraction of healthy molar teeth vs Conservative treatment (leaving the teeth in place during radiotherapy, with oral health education and disease prevention: oral hygiene, fluoride, diet advice)

Delay in start of radiation treatment · Patients diagnosed with head and neck cancer planned to undergo any type of radiotherapy (external beam, intensity modulated,…

The review found no eligible studies for this question.

1 finding from 1 review

Dental extractions prior to radiotherapy to the jaws for reducing post‐radiotherapy dental complications 2013 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Pre-radiotherapy extraction of healthy molar teeth vs Conservative treatment (leaving the teeth in place during radiotherapy, with oral health education and disease prevention: oral hygiene, fluoride, diet advice)

The review found no eligible studies for this question.

1 finding from 1 review

Dental extractions prior to radiotherapy to the jaws for reducing post‐radiotherapy dental complications 2013 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Artificial bone graft: InFuse (collagen matrix) impregnated with rhBMP-2 vs Traditional iliac crest cancellous bone graft

Clinical assessment: alveolar ridge healing (0 to 3 grading scale) · Skeletally mature patients with unilateral cleft lip and palate and an alveolar cleft defect (>5 years; mean age 16.1 years)

Artificial bone graft: InFuse (collagen matrix) impregnated with… led to higher clinical assessment: alveolar ridge healing (0 to 3 grading scale) compared with traditional iliac crest cancellous bone graft; GRADE not reported.

1 finding from 1 review

Secondary bone grafting for alveolar cleft in children with cleft lip or cleft lip and palate 2011 · Cochrane All outcomes
MD 0.90 [0.64, 1.16]
1 study · 21 participants
GRADE not reported

Secondary alveolar bone grafting performed at one timing (e.g. early secondary grafting) vs Secondary alveolar bone grafting performed at a different / optimal timing (e.g. late secondary grafting)

Outcome not reported · Patients greater than 5 years of age with unilateral or bilateral cleft lip and/or palate involving the alveolar process (complete or…

The review found no eligible studies for this question.

1 finding from 1 review

Secondary bone grafting for alveolar cleft in children with cleft lip or cleft lip and palate 2011 · Cochrane All outcomes
Furthermore, no RCTs were found to study the optimal timing ... with secondary bone grafting surgery. This systematic review has not been able to report all the objectives described in the protocol.
0 studies
No studies found

Artificial bone graft: InFuse (collagen matrix) impregnated with rhBMP-2 vs Traditional iliac crest cancellous bone graft

Radiographic assessment: periapical film (0 to 3 grading scale) · Skeletally mature patients with unilateral cleft lip and palate and an alveolar cleft defect (>5 years; mean age 16.1 years)

Artificial bone graft: InFuse (collagen matrix) impregnated with… led to higher radiographic assessment: periapical film (0 to 3 grading scale) compared with traditional iliac crest cancellous bone graft; GRADE not reported.

1 finding from 1 review

Secondary bone grafting for alveolar cleft in children with cleft lip or cleft lip and palate 2011 · Cochrane All outcomes
1 year
MD 0.60 [0.30, 0.90]
1 study · 21 participants
GRADE not reported

Secondary alveolar bone grafting with a given sequence of orthodontic treatment (e.g. orthodontics before grafting) vs Secondary alveolar bone grafting with a different sequence of orthodontic treatment (e.g. orthodontics after grafting)

Outcome not reported · Patients greater than 5 years of age with unilateral or bilateral cleft lip and/or palate involving the alveolar process (complete or…

The review found no eligible studies for this question.

1 finding from 1 review

Secondary bone grafting for alveolar cleft in children with cleft lip or cleft lip and palate 2011 · Cochrane All outcomes
No RCTs were found to study ... the sequence of orthodontic treatment with secondary bone grafting surgery.
0 studies
No studies found

Artificial bone graft: InFuse (collagen matrix) impregnated with rhBMP-2 vs Traditional iliac crest cancellous bone graft

Length of hospital stay · Skeletally mature patients with unilateral cleft lip and palate and an alveolar cleft defect (>5 years; mean age 16.1 years)

Artificial bone graft: InFuse (collagen matrix) impregnated with… led to lower length of hospital stay (days) compared with traditional iliac crest cancellous bone graft; GRADE not reported.

1 finding from 1 review

Secondary bone grafting for alveolar cleft in children with cleft lip or cleft lip and palate 2011 · Cochrane All outcomes
MD -1.40 [-1.92, -0.88]
1 study · 21 participants
GRADE not reported

Traditional iliac bone graft plus fibrin glue vs Traditional iliac bone graft alone

Radiographic assessment: coronal bone volume (cm3) · Patients aged 7 to 16 years with unilateral or bilateral cleft lip and palate (alveolar cleft)

Traditional iliac bone graft plus fibrin glue led to higher radiographic assessment: coronal bone volume (cm3) compared with traditional iliac bone graft alone; GRADE not reported.

1 finding from 1 review

Secondary bone grafting for alveolar cleft in children with cleft lip or cleft lip and palate 2011 · Cochrane All outcomes
At least 3 months
MD 42.62 [20.99, 64.25]
1 study · 27 participants
GRADE not reported

Artificial bone graft: InFuse (collagen matrix) impregnated with rhBMP-2 vs Traditional iliac crest cancellous bone graft

Postoperative complication: persistent oronasal fistula · Skeletally mature patients with unilateral cleft lip and palate and an alveolar cleft defect (>5 years; mean age 16.1 years)

Artificial bone graft: InFuse (collagen matrix) impregnated with… showed no clear difference in postoperative complication: persistent oronasal fistula compared with traditional iliac crest cancellous bone graft; GRADE not reported.

1 finding from 1 review

Secondary bone grafting for alveolar cleft in children with cleft lip or cleft lip and palate 2011 · Cochrane All outcomes
RR 0.19 [0.01, 3.23]
1 study · 21 participants
GRADE not reported

Traditional iliac bone graft plus fibrin glue vs Traditional iliac bone graft alone

Wound infection · Patients aged 7 to 16 years with unilateral or bilateral cleft lip and palate (alveolar cleft)

Traditional iliac bone graft plus fibrin glue showed no clear difference in postoperative complication: wound infection compared with traditional iliac bone graft alone; GRADE not reported.

1 finding from 1 review

Secondary bone grafting for alveolar cleft in children with cleft lip or cleft lip and palate 2011 · Cochrane All outcomes
At least 3 months
RR 3.23 [0.14, 100]
1 study · 27 participants
GRADE not reported

Artificial bone graft: InFuse (collagen matrix) impregnated with rhBMP-2 vs Traditional iliac crest cancellous bone graft

Radiographic assessment: three-dimensional CT scan (0 to 3 grading scale) · Skeletally mature patients with unilateral cleft lip and palate and an alveolar cleft defect (>5 years; mean age 16.1 years)

Artificial bone graft: InFuse (collagen matrix) impregnated with… led to higher radiographic assessment: three-dimensional CT scan (0 to 3 grading… compared with traditional iliac crest cancellous bone graft; GRADE not reported.

1 finding from 1 review

Secondary bone grafting for alveolar cleft in children with cleft lip or cleft lip and palate 2011 · Cochrane All outcomes
1 year
MD 0.90 [0.41, 1.39]
1 study · 21 participants
GRADE not reported