Recurrence of any episodes at one year for clinical worsening with additional psychotropics (mood stabilizers, antidepressants, antipsychotics or benzodiazepines) · bipolar disorder
Lamotrigine probably leads to lower recurrence of any episodes at one year for clinical worsening with… compared with placebo (moderate certainty).
1 finding from 1 review
Recurrence of any episodes at one year (active suicidal behavior) · bipolar disorder
1 finding from 1 review
no estimate extracted
1 study · 1 participants
GRADE not reported
Treatment withdrawal · bipolar disorder
It is very uncertain whether lamotrigine changes withdrawal from treatment due to any reason, up to 12 weeks after… compared with placebo (very low certainty).
1 finding from 1 review
Withdrawal from treatment due to any reason, 6‐12 months after intervention initiation (long term) · bipolar disorder
Lamotrigine probably leads to lower withdrawal from treatment due to any reason, 6‐12 months after… compared with placebo (moderate certainty).
1 finding from 1 review
Any reported adverse effects up to 12 weeks after starting treatment (short term) · bipolar disorder
It is very uncertain whether lamotrigine changes any reported adverse effects up to 12 weeks after starting treatment… compared with placebo (very low certainty).
1 finding from 1 review
Any reported adverse effects 6‐12 months after initiating the intervention (long term) · bipolar disorder
Lamotrigine showed no clear difference in any reported adverse effects 6‐12 months after initiating the… compared with placebo (moderate certainty).
1 finding from 1 review
Efficacy: response (categorical) YMRS/SADS‐C decrease ≥ 50% by end of study · acute mania
The review found no eligible studies for this question.
1 finding from 1 review
Lithium for acute mania 2019 · Cochrane Headline outcomes only no estimate extracted
Studies not reported
No studies found
Efficacy: response (continuous) change in BPRS (total) from baseline to end of study ‐all data · acute mania
1 finding from 1 review
Efficacy: remission (categorical) YMRS ≤ 12 and no increase in MADRS at end of study · acute mania
The review found no eligible studies for this question.
1 finding from 1 review
Lithium for acute mania 2019 · Cochrane Headline outcomes only no estimate extracted
Studies not reported
No studies found
Acceptability: total withdrawals · acute mania
It is very uncertain whether lithium changes acceptability: total withdrawals compared with lamotrigine (very low certainty).
1 finding from 1 review
Adverse event: tremor · acute mania
Lithium showed no clear difference in adverse event: tremor compared with lamotrigine (moderate certainty).
1 finding from 1 review
Somnolence · acute mania
Lithium showed no clear difference in adverse event: somnolence compared with lamotrigine (moderate certainty).
1 finding from 1 review