Findings

What do systematic reviews say?

29 questions · 29 findings · 3 reviews · Haematology

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No studies found 10 · 34.5%GRADE not reported 1 · 3.4%Very low 9 · 31%Low 7 · 24.1%Moderate 2 · 6.9%High 0 · 0%

GM-CSF vs placebo

Mortality (12 months · newly diagnosed patients with myelodysplastic syndromes

GM‐CSF showed no clear difference in mortality (12 months compared with placebo (low certainty).

1 finding from 1 review

Granulocyte and granulocyte‐macrophage colony stimulating factors for newly diagnosed patients with myelodysplastic… 2016 · Cochrane Headline outcomes only
HR 0.88 [0.62, 1.26]
2 studies · 149 participants
Low

GM-CSF vs placebo

Progression‐free survival · newly diagnosed patients with myelodysplastic syndromes

1 finding from 1 review

Granulocyte and granulocyte‐macrophage colony stimulating factors for newly diagnosed patients with myelodysplastic… 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 149 participants
Low

Intervention not reported

All cause mortality · patients with myelodysplastic syndrome

It is very uncertain whether the intervention changes all cause mortality (very low certainty).

1 finding from 1 review

Comparison of a restrictive versus liberal red cell transfusion policy for patients with myelodysplasia, aplastic… 2015 · Cochrane Headline outcomes only
RR 0.13 [0.01, 2.32]
1 study · 13 participants
Very low

Intervention not reported

Mortality secondary to bleeding/infection/transfusion reactions or iron overload ‐ not reported · patients with myelodysplastic syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Comparison of a restrictive versus liberal red cell transfusion policy for patients with myelodysplasia, aplastic… 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Quality of life ‐ not reported · patients with myelodysplastic syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Comparison of a restrictive versus liberal red cell transfusion policy for patients with myelodysplasia, aplastic… 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Frequency and length of hospital admissions ‐ not reported · patients with myelodysplastic syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Comparison of a restrictive versus liberal red cell transfusion policy for patients with myelodysplasia, aplastic… 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Serious infections (requiring admission to hospital) ‐ not reported · patients with myelodysplastic syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Comparison of a restrictive versus liberal red cell transfusion policy for patients with myelodysplasia, aplastic… 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Serious bleeding (e.g. WHO/CTCAE grade 3 (or equivalent) or above ) ‐ not reported · patients with myelodysplastic syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Comparison of a restrictive versus liberal red cell transfusion policy for patients with myelodysplasia, aplastic… 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Red blood cell transfusion requirements (units of red blood cells per patient per month) · patients with myelodysplastic syndrome

1 finding from 1 review

Comparison of a restrictive versus liberal red cell transfusion policy for patients with myelodysplasia, aplastic… 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 13 participants
Very low