Efficacy: number of participants who respond to treatment ‐ at 24 hours · adults with Major Depressive Disorder
Esketamine may leads to higher efficacy: number of participants who respond to treatment ‐ at 24… compared with placebo (low certainty).
1 finding from 1 review
OR 2.11 [1.2, 3.68]
Studies not reported
Low
Remission · adults with Major Depressive Disorder
Esketamine probably leads to higher efficacy: number of participants who achieve remission ‐ at 24 hours… compared with placebo (moderate certainty).
1 finding from 1 review
OR 2.74 [1.71, 4.4]
Studies not reported
Moderate
Depressive symptoms · adults with Major Depressive Disorder
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Acceptability ‐ total dropouts · adults with Major Depressive Disorder
Esketamine showed no clear difference in acceptability: total dropouts№ of participants: 773(5 RCTs) compared with placebo (moderate certainty).
1 finding from 1 review
OR 1.58 [0.92, 2.73]
Studies not reported
Moderate
Withdrawals due to adverse events · adults with Major Depressive Disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Efficacy: number of participants who respond to treatment ‐ at 3 months · adults (aged 18 years+) with depression in bipolar disorder
It is very uncertain whether memantine changes efficacy: number of participants who respond to treatment ‐ at 1 week compared with placebo (very low certainty).
4 findings from 1 review
OR 1.08 [0.06, 19.05]
1 study · 29 participants
Very low
OR 4.88 [0.78, 30.29]
1 study · 29 participants
Very low
OR 5.33 [1.02, 27.76]
1 study · 29 participants
Very low
Show 1 more finding
Remission · adults (aged 18 years+) with depression in bipolar disorder
It is very uncertain whether memantine changes efficacy: number of participants who achieve remission ‐ at 1 week compared with placebo (very low certainty).
1 finding from 1 review
Depressive symptoms · adults (aged 18 years+) with depression in bipolar disorder
1 finding from 1 review
Acceptability ‐ total dropouts · adults (aged 18 years+) with depression in bipolar disorder
Memantine showed no clear difference in acceptability: total dropouts compared with placebo (low certainty).
1 finding from 1 review
Acceptability ‐ dropouts due to adverse effects · adults (aged 18 years+) with depression in bipolar disorder
Memantine showed no clear difference in acceptability: dropouts due to adverse effects compared with placebo (low certainty).
1 finding from 1 review
Efficacy: number of participants who respond to treatment ‐ at 3 months · adults (aged 18 years+) with depression in bipolar disorder
It is very uncertain whether cytidine changes efficacy: number of participants who respond to treatment ‐ at 3… compared with placebo (very low certainty).
1 finding from 1 review
Remission · adults (aged 18 years+) with depression in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Depression rating scale score · adults (aged 18 years+) with depression in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Acceptability ‐ total dropouts · adults (aged 18 years+) with depression in bipolar disorder
It is very uncertain whether cytidine changes acceptability: total dropouts compared with placebo (very low certainty).
1 finding from 1 review
Acceptability ‐ dropouts due to adverse effects · adults (aged 18 years+) with depression in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Efficacy: number of participants who respond to treatment ‐ at 3 months · adults (aged 18 years+) with depression in bipolar disorder
N‐acetylcysteine showed no clear difference in efficacy: number of participants who respond to treatment ‐ at 3… compared with placebo (low certainty).
1 finding from 1 review
Remission · adults (aged 18 years+) with depression in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Depressive symptoms · adults (aged 18 years+) with depression in bipolar disorder
1 finding from 1 review
Dropout · adults (aged 18 years+) with depression in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Withdrawals due to adverse events · adults (aged 18 years+) with depression in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found