Summary of findings: Comparison 7 ‐ deferiprone (DFP) plus… may leads to lower adherence to iron chelation therapy rates (n, N) compared with DFP plus deferasirox (DFX) (low certainty).

1 finding from 1 review

Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia 2023 · Cochrane Headline outcomes only
RR 0.84 [0.72, 0.99]
1 study · 96 participants
Low

Deferasirox vs deferiprone (DFO)

Adherence to iron chelation therapy (%, SD)

1 finding from 1 review

Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 452 participants
Very low

Parenteral iron vs oral iron

All‐cause mortality · patients with anaemia

It is very uncertain whether parenteral iron changes mortality compared with oral iron (very low certainty).

1 finding from 1 review

Iron therapy in anaemic adults without chronic kidney disease 2014 · Cochrane Headline outcomes only
RR 1.49 [0.56, 3.94]
6 studies · 1009 participants
Very low

Parenteral iron vs oral iron

Blood transfusion · patients with anaemia

It is very uncertain whether parenteral iron changes proportion requiring blood transfusion compared with oral iron (very low certainty).

1 finding from 1 review

Iron therapy in anaemic adults without chronic kidney disease 2014 · Cochrane Headline outcomes only
RR 0.61 [0.24, 1.58]
2 studies · 371 participants
Very low

Parenteral iron vs oral iron

Amount of blood transfused per patient (in units) · patients with anaemia

1 finding from 1 review

Iron therapy in anaemic adults without chronic kidney disease 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 44 participants
Very low

Parenteral iron vs oral iron

Haemoglobin (g/dL) · patients with anaemia

1 finding from 1 review

Iron therapy in anaemic adults without chronic kidney disease 2014 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 769 participants
Low

Parenteral iron vs oral iron

Quality of life · patients with anaemia

1 finding from 1 review

Iron therapy in anaemic adults without chronic kidney disease 2014 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 771 participants
Very low

Parenteral iron vs oral iron

Serious adverse events · patients with anaemia

It is very uncertain whether parenteral iron changes serious adverse events compared with oral iron (very low certainty).

1 finding from 1 review

Iron therapy in anaemic adults without chronic kidney disease 2014 · Cochrane Headline outcomes only
RR 1.23 [0.99, 1.54]
7 studies · 1100 participants
Very low

Intravenous iron vs placebo

Haemoglobin (g/dL) · non‐anaemic, iron‐deficient adults

1 finding from 1 review

Intravenous iron therapy for non‐anaemic, iron‐deficient adults 2019 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 548 participants
Low

Intravenous iron vs placebo

Overall quality of life measured at the end of · non‐anaemic, iron‐deficient adults

1 finding from 1 review

Intravenous iron therapy for non‐anaemic, iron‐deficient adults 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 344 participants
Very low

Intravenous iron vs placebo

Serum ferritin (ng/mL) · non‐anaemic, iron‐deficient adults

1 finding from 1 review

Intravenous iron therapy for non‐anaemic, iron‐deficient adults 2019 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 376 participants
Very low

Intravenous iron vs placebo

Bacterial infection · non‐anaemic, iron‐deficient adults

The review found no eligible studies for this question.

1 finding from 1 review

Intravenous iron therapy for non‐anaemic, iron‐deficient adults 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intravenous iron vs placebo

Peak oxygen consumption taken at the end of · non‐anaemic, iron‐deficient adults

1 finding from 1 review

Intravenous iron therapy for non‐anaemic, iron‐deficient adults 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 32 participants
Very low

Intravenous iron vs placebo

Serious adverse events · non‐anaemic, iron‐deficient adults

The review found no eligible studies for this question.

1 finding from 1 review

Intravenous iron therapy for non‐anaemic, iron‐deficient adults 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intravenous iron vs placebo

Adverse events mild adverse events · non‐anaemic, iron‐deficient adults

It is very uncertain whether intravenous iron changes mild adverse effects compared with placebo (very low certainty).

1 finding from 1 review

Intravenous iron therapy for non‐anaemic, iron‐deficient adults 2019 · Cochrane Headline outcomes only
RR 1.19 [0.97, 1.45]
3 studies · 440 participants
Very low