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What do systematic reviews say?

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Evidence found and GRADE certainty

217 questions · 238 findings · 27 reviews · Airways

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No studies found 30 · 12.6%GRADE not reported 14 · 5.9%Very low 51 · 21.4%Low 82 · 34.5%Moderate 57 · 23.9%High 4 · 1.7%

Medical or surgical intervention, or both, for gastro‐oesophageal reflux disease vs nil intervention, delayed intervention control, or placebo

Exacerbations: number of people experiencing moderate or severe exacerbations · treatment for asthma in adults and children with asthma and GORD

Medical or surgical intervention, or both, for gastro‐oesophageal… showed no clear difference in number of participants with moderate/severe acute exacerbations… compared with nil intervention, delayed intervention control, or placebo (low certainty).

1 finding from 1 review

Medical or surgical intervention, or both, for gastro‐oesophageal reflux disease vs nil intervention, delayed intervention control, or placebo

Lung function: FEV1 mL (change from baseline) · treatment for asthma in adults and children with asthma and GORD
1 finding from 1 review

Medical or surgical intervention, or both, for gastro‐oesophageal reflux disease vs nil intervention, delayed intervention control, or placebo

Use of "rescue" medications and emergency action plans: B2 use puffs per day Duration of treatment: range 14 weeks to 24 weeks · treatment for asthma in adults and children with asthma and GORD
1 finding from 1 review

Medical or surgical intervention, or both, for gastro‐oesophageal reflux disease vs nil intervention, delayed intervention control, or placebo

Healthcare utilisation ‐ not measured · treatment for asthma in adults and children with asthma and GORD

The review found no eligible studies for this question.

1 finding from 1 review

Integrated disease management interventions vs usual care

Respiratory‐related hospital admissions · patients with chronic obstructive pulmonary disease

Integrated disease management interventions leads to lower respiratory‐related hospital admissions compared with usual care (high certainty).

1 finding from 1 review

Effects of school‐based asthma interventions vs usual care

Asthma symptoms leading to emergency hospital visits (ED visits) · children with asthma

Effects of school‐based asthma interventions may leads to lower asthma symptoms leading to emergency hospital visits (ED visits) compared with usual care (low certainty).

1 finding from 1 review