Findings

What do systematic reviews say?

375 questions · 390 findings · 22 reviews · Pain, Palliative and Supportive Care

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No studies found 117 · 30%GRADE not reported 36 · 9.2%Very low 111 · 28.5%Low 75 · 19.2%Moderate 48 · 12.3%High 3 · 0.8%

Summary of findings: complete control of vomiting during the overall phase (HEC) when vs treatment with aprepitant + granisetron

Interventions (corticosteroids included in all regimens)a · adult cancer patients at risk for CINV caused by highly emetogenic chemotherapy

The review found no eligible studies for this question.

1 finding from 1 review

Antiemetics for adults for prevention of nausea and vomiting caused by moderately or highly emetogenic chemotherapy: a… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: serious adverse events (HEC) when vs treatment with aprepitant + granisetron

Interventions (corticosteroids included in all regimens)a · adult cancer patients at risk for CINV caused by highly emetogenic chemotherapy

The review found no eligible studies for this question.

1 finding from 1 review

Antiemetics for adults for prevention of nausea and vomiting caused by moderately or highly emetogenic chemotherapy: a… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: complete control of vomiting during the overall phase (MEC) when vs treatment with granisetron

Interventions (corticosteroids included in all regimens)a · adult cancer patients at risk for CINV caused by moderately emetogenic chemotherapy

The review found no eligible studies for this question.

1 finding from 1 review

Antiemetics for adults for prevention of nausea and vomiting caused by moderately or highly emetogenic chemotherapy: a… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: serious adverse events (MEC) when vs treatment with granisetron

Interventions (corticosteroids included in all regimens)a · adult cancer patients at risk for CINV caused by moderately emetogenic chemotherapy

The review found no eligible studies for this question.

1 finding from 1 review

Antiemetics for adults for prevention of nausea and vomiting caused by moderately or highly emetogenic chemotherapy: a… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intravenous ketorolac vs NSAIDs

Number of women requiring rescue medication · adults (mean study ages 23 to 67 years) with acute postoperative pain after abdominal/pelvic, dental or orthopedic surgeries

It is very uncertain whether intravenous ketorolac changes number of participants using rescue medication over 4 or 6 hours… compared with another NSAID (very low certainty).

1 finding from 1 review

Single‐dose intravenous ketorolac for acute postoperative pain in adults 2021 · Cochrane Headline outcomes only
RR 0.9 [0.58, 1.4]
3 studies · 260 participants
Very low

Intravenous ketorolac vs placebo

Use of rescue medication · adults (mean study ages 23 to 67 years) with acute postoperative pain after abdominal/pelvic, dental or orthopedic surgeries

It is very uncertain whether intravenous ketorolac changes number of participants using rescue medication over 4 or 6 hours… compared with placebo (very low certainty).

1 finding from 1 review

Single‐dose intravenous ketorolac for acute postoperative pain in adults 2021 · Cochrane Headline outcomes only
RR 0.6 [0.36, 1]
5 studies · 417 participants
Very low

Intravenous diclofenac vs NSAIDs

Number of participants using rescue medication over 4 to 6 hours postinterventions · Adults (mean study ages 25 to 55 years) with acute postoperative pain after dental, mixed minor, abdominal, or orthopedic surgeries

It is very uncertain whether intravenous diclofenac changes number of participants using rescue medication over 4 to 6 hours… compared with another NSAID (very low certainty).

1 finding from 1 review

Single‐dose intravenous diclofenac for acute postoperative pain in adults 2018 · Cochrane Headline outcomes only
RR 1.8 [1, 3.3]
1 study · 98 participants
Very low

Intravenous diclofenac vs placebo

Intravenous diclofenac may leads to lower number of participants using rescue medication over 4 to 6 hours… compared with placebo (low certainty).

1 finding from 1 review

Single‐dose intravenous diclofenac for acute postoperative pain in adults 2018 · Cochrane Headline outcomes only
RR 0.59 [0.48, 0.73]
2 studies · 235 participants
Low

Intervention not reported

Talc poudrage (4 RCTs; 553 participants) · adults with malignant pleural effusion Interventions: talc poudrage, bleomycin, IPC – not daily drainage, doxycycline, placebo Comparator…

1 finding from 1 review

Interventions for the management of malignant pleural effusions: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 553 participants
Low

Intervention not reported

Bleomycin (14 RCTs; 774 participants) · adults with malignant pleural effusion Interventions: talc poudrage, bleomycin, IPC – not daily drainage, doxycycline, placebo Comparator…

1 finding from 1 review

Interventions for the management of malignant pleural effusions: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
14 studies · 774 participants
Low

Intervention not reported

IPC – not daily drainage (1 RCT; 101 participants) · adults with malignant pleural effusion Interventions: talc poudrage, bleomycin, IPC – not daily drainage, doxycycline, placebo Comparator…

1 finding from 1 review

Interventions for the management of malignant pleural effusions: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 101 participants
Low

Intervention not reported

Doxycycline (4 RCTs; 308 participants) · adults with malignant pleural effusion Interventions: talc poudrage, bleomycin, IPC – not daily drainage, doxycycline, placebo Comparator…

1 finding from 1 review

Interventions for the management of malignant pleural effusions: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 308 participants
Low

Intervention not reported

Placebo (2 RCTs; 118 participants) · adults with malignant pleural effusion Interventions: talc poudrage, bleomycin, IPC – not daily drainage, doxycycline, placebo Comparator…

1 finding from 1 review

Interventions for the management of malignant pleural effusions: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 118 participants
Low

Intervention not reported

Talc slurry (9 RCTs, 1320 participants) · adults with malignant pleural effusion Interventions: talc poudrage, bleomycin IPC – not daily drainage, doxycycline, placebo Comparator…

1 finding from 1 review

Interventions for the management of malignant pleural effusions: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 1320 participants
Low

Intervention not reported

Talc poudrage (4 RCTs, 886 participants) · adults with malignant pleural effusion Interventions: talc poudrage, bleomycin IPC – not daily drainage, doxycycline, placebo Comparator…

1 finding from 1 review

Interventions for the management of malignant pleural effusions: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 886 participants
Very low

Intervention not reported

Bleomycin (13 RCTs, 724 participants) · adults with malignant pleural effusion Interventions: talc poudrage, bleomycin IPC – not daily drainage, doxycycline, placebo Comparator…

1 finding from 1 review

Interventions for the management of malignant pleural effusions: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 724 participants
Low

Intervention not reported

IPC – not daily drainage (6 RCTs, 738 participants) · adults with malignant pleural effusion Interventions: talc poudrage, bleomycin IPC – not daily drainage, doxycycline, placebo Comparator…

1 finding from 1 review

Interventions for the management of malignant pleural effusions: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 738 participants
Low

Intervention not reported

Talc slurry (19 RCTs, 907 participants) · adults with malignant pleural effusion Interventions: talc poudrage, bleomycin, IPC – not daily drainage, doxycycline, placebo Comparator…

1 finding from 1 review

Interventions for the management of malignant pleural effusions: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
19 studies · 907 participants
Moderate

Intervention not reported

Doxycycline (4 RCTs, 308 participants) · adults with malignant pleural effusion Interventions: talc poudrage, bleomycin IPC – not daily drainage, doxycycline, placebo Comparator…

1 finding from 1 review

Interventions for the management of malignant pleural effusions: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 308 participants
Low

Intervention not reported

Placebo · adults with malignant pleural effusion Interventions: talc poudrage, bleomycin IPC – not daily drainage, doxycycline, placebo Comparator…

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for the management of malignant pleural effusions: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found