Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

77 questions · 78 findings · 5 reviews · Other oral health

No studies found 6 · 7.7%GRADE not reported 67 · 85.9%Very low 4 · 5.1%Low 0 · 0%Moderate 1 · 1.3%High 0 · 0%

Individually designed, patient-centred preventive programme: dietary counselling (snacking timing, regular meals, fermentable carbohydrates) plus toothbrushing counselling, delivered by trained dental hygienists (a multi-intervention) vs Basic prevention offered as standard in public dental clinics

Eating healthy snacks at least twice per day · Children aged 11 to 12 years with at least one active initial caries lesion, screened in a town in Finland
1 finding from 1 review

Individually designed, patient-centred preventive programme: dietary counselling (snacking timing, regular meals, fermentable carbohydrates) plus toothbrushing counselling, delivered by trained dental hygienists (a multi-intervention) vs Basic prevention offered as standard in public dental clinics

Eating warm meals more than twice per day · Children aged 11 to 12 years with at least one active initial caries lesion, screened in a town in Finland
1 finding from 1 review

Individually designed, patient-centred preventive programme: dietary counselling (snacking timing, regular meals, fermentable carbohydrates) plus toothbrushing counselling, delivered by trained dental hygienists (a multi-intervention) vs Basic prevention offered as standard in public dental clinics

Drinking sports drinks no more than once per week · Children aged 11 to 12 years with at least one active initial caries lesion, screened in a town in Finland
1 finding from 1 review

Individually designed, patient-centred preventive programme: dietary counselling (snacking timing, regular meals, fermentable carbohydrates) plus toothbrushing counselling, delivered by trained dental hygienists (a multi-intervention) vs Basic prevention offered as standard in public dental clinics

Using xylitol products more than 3 times per day · Children aged 11 to 12 years with at least one active initial caries lesion, screened in a town in Finland

Individually designed, patient-centred preventive programme: dietary… led to higher using xylitol products more than 3 times per day compared with basic prevention offered as standard in public dental clinics; GRADE not reported.

1 finding from 1 review

Cyclosporin (systemic; 10 mg/kg/day for 16 weeks) vs Colchicine (systemic; 1 mg daily)

Safety of the intervention (adverse effects) · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review

Thalidomide (systemic; 100 mg or 300 mg daily) vs placebo

Safety of the intervention (adverse effects) · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • Interventions for managing oral ulcers in Behçet's disease 2014 · Cochrane All outcomes
    Males only
    Hamuryudan 1998: significant adverse effects including severe sedation, polyneuropathy, loss of libido, and weight gain; a greater number of adverse events was seen for the higher (300 mg) dose; 4 patients withdrew due…
    1 study · 101 participants
    GRADE not reported

Interferon-alpha (systemic) vs Placebo (subcutaneous)

Safety of the intervention (adverse effects) · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • Alpsoy 2002: high rate of adverse events including alopecia, leukopenia, and diarrhoea; 18 of 23 patients in the treatment arm experienced mild flu-like symptoms.
    1 study · 50 participants
    GRADE not reported

Fee‐for‐service (FFS) vs no intervention or control intervention (control)

Healthcare costs: cost-effectiveness of fee-for-service vs control (incremental cost-effectiveness ratio, reported as % change in outcome per GBP; currency year NR) · Dentists seeing children with erupted second permanent molars (Scotland, in areas representing the four most deprived categories out of…
1 finding from 1 review

Fee‐for‐service (FFS) vs no intervention or control intervention (control)

Measures of clinical activity: mean percentage of 12- to 14-year-olds receiving fissure sealants for second permanent molars per dentist (weighted by number of children seen) - unadjusted · Dentists seeing children with erupted second permanent molars (Scotland, in areas representing the four most deprived categories out of…

It is very uncertain whether fee-for-service remuneration changes measures of clinical activity: mean percentage of 12- to… compared with no specific intervention (control) (very low certainty).

1 finding from 1 review

Fee‐for‐service (FFS) vs no intervention or control intervention (control)

Measures of clinical activity: mean percentage of 12- to 14-year-olds receiving fissure sealants for second permanent molars per dentist (weighted by number of children seen) - adjusted · Dentists seeing children with erupted second permanent molars (Scotland, in areas representing the four most deprived categories out of…

It is very uncertain whether fee-for-service remuneration changes measures of clinical activity: mean percentage of 12- to… compared with no specific intervention (control) (very low certainty).

1 finding from 1 review

Pedicled buccal fat pad flap (PBFPF) vs Buccal flap (BF)

Successful (complete) closure of oro-antral communication · People of any age with oro-antral communications, fistulae, or both caused by dental procedures

It is very uncertain whether pedicled buccal fat pad flap (PBFPF) changes successful (complete) closure of oro-antral communication compared with buccal flap (BF) (very low certainty).

1 finding from 1 review

Sucralfate suspension (topical) vs Placebo suspension

Duration of episodes · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care

Sucralfate suspension (topical) showed no clear difference in mean duration of episodes compared with placebo suspension; GRADE not reported.

1 finding from 1 review

Interferon-alpha (topical lozenges) vs placebo

Total ulcer burden · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • Kilic 2009 (interferon-alpha lozenges 1000 IU or 2000 IU vs placebo, 84 patients; high risk of selective reporting): the data presented did not allow analysis; authors reported no statistically significant difference…
    1 study · 84 participants
    GRADE not reported