What do systematic reviews say?

Intervention not reported

The intervention leads to lower moderate to severe exacerbations ‐ TRIPLE vs DUAL№ of participants:… (high certainty).

• Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and varying… 2022 · Cochrane Headline outcomes only
  RR 0.85 [0.78, 0.92]
  5 studies · 8173 participants
  High

Intervention not reported

• Addition of long‐acting beta2 agonists or long‐acting muscarinic antagonists versus doubling the dose of inhaled… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  Low

Intervention not reported

• Addition of long‐acting beta2 agonists or long‐acting muscarinic antagonists versus doubling the dose of inhaled… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 679 participants
  Low

Intervention not reported

• Addition of long‐acting beta2 agonists or long‐acting muscarinic antagonists versus doubling the dose of inhaled… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  12 studies · 7569 participants
  Moderate

Intervention not reported

• Addition of long‐acting beta2 agonists or long‐acting muscarinic antagonists versus doubling the dose of inhaled… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 1759 participants
  Moderate

Intervention not reported

The review found no eligible studies for this question.

• Addition of long‐acting beta2 agonists or long‐acting muscarinic antagonists versus doubling the dose of inhaled… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

• Addition of long‐acting beta2 agonists or long‐acting muscarinic antagonists versus doubling the dose of inhaled… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  25 studies · 25583 participants
  GRADE not reported

Intervention not reported

• Addition of long‐acting beta2 agonists or long‐acting muscarinic antagonists versus doubling the dose of inhaled… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 1685 participants
  Moderate

Intervention not reported

• Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and varying… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  10 studies · 12407 participants
  GRADE not reported

Intervention not reported

• Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and varying… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 5452 participants
  High

Intervention not reported

• Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and varying… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 3184 participants
  Moderate

Intervention not reported

• Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and varying… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 2037 participants
  High

Intervention not reported

The review found no eligible studies for this question.

• Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and varying… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and varying… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

• Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and varying… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 3470 participants
  Moderate

Intervention not reported

The review found no eligible studies for this question.

• Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and varying… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found