Findings

What do systematic reviews say?

31 questions · 35 findings · 4 reviews · Metabolic and Endocrine Disorders

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No studies found 15 · 42.9%GRADE not reported 0 · 0%Very low 10 · 28.6%Low 7 · 20%Moderate 3 · 8.6%High 0 · 0%

Insulin glargine vs NPH insulin

Health‐related quality of life

1 finding from 1 review

(Ultra‐)long‐acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes… 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 1228 participants
Very low

Insulin glargine vs NPH insulin

All‐cause mortality

Insulin glargine showed no clear difference in all‐cause mortality compared with NPH insulin (low certainty).

1 finding from 1 review · compare the 2 reviews

(Ultra‐)long‐acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes… 2020 · Cochrane Headline outcomes only
Peto OR 1.06 [0.62, 1.82]
14 studies · 6173 participants
Low

Insulin glargine vs NPH insulin

AEs other than hypoglycaemia (1) SAE (2) Overall AE (3) AE leading to discontinuation

Insulin glargine showed no clear difference in AEs other than hypoglycaemia (1) SAE (2) Overall AE (3) AE leading… compared with NPH insulin (moderate certainty).

1 finding from 1 review

(Ultra‐)long‐acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes… 2020 · Cochrane Headline outcomes only
RR 0.98 [0.87, 1.1]
1 study · 13 participants
Moderate

Insulin glargine vs NPH insulin

Socioeconomic effects

The review found no eligible studies for this question.

1 finding from 1 review

(Ultra‐)long‐acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Insulin glargine vs NPH insulin

HbA1c (%)

1 finding from 1 review · compare the 2 reviews

(Ultra‐)long‐acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes… 2020 · Cochrane Headline outcomes only
no estimate extracted
16 studies · 5809 participants
Low

Intervention not reported

Diabetic ketoacidosis · healthy physicians

The review found no eligible studies for this question.

1 finding from 1 review

Thermal stability and storage of human insulin 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Hypoglycaemic episodes · healthy physicians

The review found no eligible studies for this question.

1 finding from 1 review

Thermal stability and storage of human insulin 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Adverse events · healthy physicians

The review found no eligible studies for this question.

1 finding from 1 review

Thermal stability and storage of human insulin 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Health‐related quality of life · healthy physicians

The review found no eligible studies for this question.

1 finding from 1 review

Thermal stability and storage of human insulin 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

HbA1c · healthy physicians

The review found no eligible studies for this question.

1 finding from 1 review

Thermal stability and storage of human insulin 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Mean fall in plasma glucose levels (mmol/L/min) · healthy physicians

1 finding from 1 review

Thermal stability and storage of human insulin 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 8 participants
Very low