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Evidence found and GRADE certainty

40 questions · 42 findings · 3 reviews · Eyes and Vision

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No studies found 5 · 11.9%GRADE not reported 2 · 4.8%Very low 6 · 14.3%Low 3 · 7.1%Moderate 18 · 42.9%High 8 · 19%

Summary of findings 2: Efficacy and safety of IVT lampalizumab 6‐ to 8‐weekly (every other month) vs sham

Loss of ≥ 15 letters BCVA at 1 year · adults with GA due to AMD

Summary of findings 2: Efficacy and safety of IVT lampalizumab 6‐ to… showed no clear difference in loss of ≥ 15 letters BCVA at 1 year compared with sham (moderate certainty).

1 finding from 1 review

Silicone hydrogel vs hydrogel soft contact lenses

Comfort · Adults with refractive errors

The review found no eligible studies for this question.

3 findings from 1 review

Silicone hydrogel vs hydrogel soft contact lenses

Proportion of participants who discontinued contact lens wear, at 1 week (RR < 1 favored) · Adults with refractive errors

It is very uncertain whether silicone hydrogel changes proportion of participants who discontinued contact lens wear, at 1… compared with hydrogel soft contact lenses (very low certainty).

1 finding from 1 review

Silicone hydrogel vs hydrogel soft contact lenses

Corneal staining scores, at 1 week (MD < 0 favored) · Adults with refractive errors

It is very uncertain whether silicone hydrogel changes corneal staining scores, at 1 week (MD < 0 favored) compared with hydrogel soft contact lenses (very low certainty).

1 finding from 1 review

Silicone hydrogel vs hydrogel soft contact lenses

Conjunctival staining scores, at 1 month (MD < 0 favored) · Adults with refractive errors

It is very uncertain whether silicone hydrogel changes conjunctival staining scores, at 1 month (MD < 0 favored) compared with hydrogel soft contact lenses (very low certainty).

1 finding from 1 review