Safety: Development of endophthalmitis at 1 year · adults with GA due to AMD
Summary of findings 1: Efficacy and safety of IVT lampalizumab… showed no clear difference in safety: Development of endophthalmitis at 1 year compared with sham (moderate certainty).
1 finding from 1 review
Safety: Development of macular neovascularisation or exudative AMD at 1 year · adults with GA due to AMD
Summary of findings 3: Efficacy and safety of IVT pegcetacoplan… showed no clear difference in safety: Development of macular neovascularisation or exudative AMD… compared with sham; GRADE not reported.
1 finding from 1 review
Safety: Development of endophthalmitis at 1 year · adults with GA due to AMD
Summary of findings 3: Efficacy and safety of IVT pegcetacoplan… showed no clear difference in safety: Development of endophthalmitis at 1 year compared with sham (moderate certainty).
1 finding from 1 review
Safety: Development of macular neovascularisation or exudative AMD at 1 year · adults with GA due to AMD
Summary of findings 4: Efficacy and safety of IVT pegcetacoplan… showed no clear difference in safety: Development of macular neovascularisation or exudative AMD… compared with sham; GRADE not reported.
1 finding from 1 review
Safety: Development of endophthalmitis at 1 year · adults with GA due to AMD
Summary of findings 4: Efficacy and safety of IVT pegcetacoplan… showed no clear difference in safety: Development of endophthalmitis at 1 year compared with sham (moderate certainty).
1 finding from 1 review
Safety: Development of macular neovascularisation or exudative AMD at 1 year · adults with GA due to AMD
Summary of findings 2: Efficacy and safety of IVT lampalizumab 6‐ to… showed no clear difference in safety: Development of macular neovascularisation or exudative AMD… compared with sham (low certainty).
1 finding from 1 review
Safety: Development of endophthalmitis at 1 year · adults with GA due to AMD
Summary of findings 2: Efficacy and safety of IVT lampalizumab 6‐ to… showed no clear difference in safety: Development of endophthalmitis at 1 year compared with sham (moderate certainty).
1 finding from 1 review
Caesarean section ‐ ST analysis · Pregnant women (and their fetuses) in labour, with a perceived need for continuous electronic fetal heart rate monitoring
Fetal electrocardiogram (ECG) (ST analysis) plus cardiotocography… showed no clear difference in caesarean section ‐ ST analysis compared with CTG alone (high certainty).
1 finding from 1 review
Cord pH less than 7.05 and base deficit greater than 12 mmol/L ‐ ST analysis · Pregnant women (and their fetuses) in labour, with a perceived need for continuous electronic fetal heart rate monitoring
Fetal electrocardiogram (ECG) (ST analysis) plus cardiotocography… showed no clear difference in cord pH less than 7.05 and base deficit greater than 12 mmol/L ‐ ST… compared with CTG alone (moderate certainty).
1 finding from 1 review
Neonatal encephalopathy ‐ ST analysis · Pregnant women (and their fetuses) in labour, with a perceived need for continuous electronic fetal heart rate monitoring
Fetal electrocardiogram (ECG) (ST analysis) plus cardiotocography… showed no clear difference in neonatal encephalopathy ‐ ST analysis compared with CTG alone (high certainty).
1 finding from 1 review
Instrumental vaginal birth · Pregnant women (and their fetuses) in labour, with a perceived need for continuous electronic fetal heart rate monitoring
Fetal electrocardiogram (ECG) (ST analysis) plus cardiotocography… leads to lower operative vaginal delivery ‐ ST analysis compared with CTG alone (high certainty).
1 finding from 1 review
Neonatal admission to special care · Pregnant women (and their fetuses) in labour, with a perceived need for continuous electronic fetal heart rate monitoring
Fetal electrocardiogram (ECG) (ST analysis) plus cardiotocography… showed no clear difference in admission to neonatal special care unit ‐ ST analysis compared with CTG alone (high certainty).
1 finding from 1 review
Any perinatal death after randomisation · Pregnant women (and their fetuses) in labour, with a perceived need for continuous electronic fetal heart rate monitoring
Fetal electrocardiogram (ECG) (ST analysis) plus cardiotocography… showed no clear difference in perinatal death ‐ ST analysis compared with CTG alone (high certainty).
1 finding from 1 review
Fetal mortality · pregnant women with fetal growth restriction
1 finding from 1 review
Fetal mortality · pregnant women with fetal growth restriction
Sildenafil citrate showed no clear difference in fetal mortality compared with placebo or no therapy (moderate certainty).
1 finding from 1 review
Fetal mortality · pregnant women with fetal growth restriction
Tadalafil showed no clear difference in fetal mortality compared with placebo or no therapy (low certainty).
1 finding from 1 review
Fetal mortality · pregnant women with fetal growth restriction
1 finding from 1 review
Any known death after randomisation (fetal, neonatal, child, child as adult) · women at risk of preterm birth
It is very uncertain whether dexamethasone: oral changes any known death after randomisation (fetal, neonatal, child, child… compared with intramuscular – fetal/neonatal outcomes (very low certainty).
1 finding from 1 review
Any known death after randomisation (fetal, neonatal, child, child as adult) · women at risk of preterm birth
It is very uncertain whether betamethasone acetate plus phosphate changes any known death after randomisation (fetal, neonatal, child, child… compared with betamethasone phosphate – fetal/neonatal outcomes (very low certainty).
1 finding from 1 review
Any known death after randomisation (fetal, neonatal, child, child as adult) · women at risk of preterm birth
It is very uncertain whether betamethasone 12‐hourly changes any known death after randomisation (fetal, neonatal, child, child… compared with 24‐hourly dosing – fetal/neonatal outcomes (very low certainty).
1 finding from 1 review