What do systematic reviews say?

Glutamine vs placebo

The review found no eligible studies for this question.

• Interventions for prophylaxis of hepatic veno‐occlusive disease in people undergoing haematopoietic stem cell… 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Glutamine vs placebo

It is very uncertain whether summary of findings: Glutamine changes frequency of adverse events ( compared with placebo (very low certainty).

• Interventions for prophylaxis of hepatic veno‐occlusive disease in people undergoing haematopoietic stem cell… 2015 · Cochrane Headline outcomes only
  RR 2.68 [0.12, 61.58]
  1 study · 34 participants
  Very low

Arginine, glutamine and β‐hydroxy‐β‐methylbutyrate supplement vs placebo

The review found no eligible studies for this question.

• Nutritional interventions for treating foot ulcers in people with diabetes 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Arginine, glutamine and β‐hydroxy‐β‐methylbutyrate supplement vs placebo

It is very uncertain whether arginine, glutamine and β‐hydroxy‐β‐methylbutyrate supplement changes development of any new foot ulcers compared with placebo (very low certainty).

• Nutritional interventions for treating foot ulcers in people with diabetes 2020 · Cochrane Headline outcomes only
  RR 1.04
  1 study · 270 participants
  Very low

Arginine, glutamine and β‐hydroxy‐β‐methylbutyrate supplement vs placebo

It is very uncertain whether arginine, glutamine and β‐hydroxy‐β‐methylbutyrate supplement changes amputation rate compared with placebo (very low certainty).

• Nutritional interventions for treating foot ulcers in people with diabetes 2020 · Cochrane Headline outcomes only
  RR 0.66 [0.16, 2.69]
  1 study · 270 participants
  Very low

Arginine, glutamine and β‐hydroxy‐β‐methylbutyrate supplement vs placebo

The review found no eligible studies for this question.

• Nutritional interventions for treating foot ulcers in people with diabetes 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found
• Nutritional interventions for treating foot ulcers in people with diabetes 2020 · Cochrane Headline outcomes only
  RR 1.09 [0.85, 1.4]
  1 study · 270 participants
  Very low

Arginine, glutamine and β‐hydroxy‐β‐methylbutyrate supplement vs placebo

It is very uncertain whether arginine, glutamine and β‐hydroxy‐β‐methylbutyrate supplement changes quality of life compared with placebo (very low certainty).

• Nutritional interventions for treating foot ulcers in people with diabetes 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 270 participants
  Very low

Enteral nutrition via nasojejunal tube plus intravenous glutamine‐dipeptide supplementation vs parenteral nutrition

It is very uncertain whether enteral nutrition via nasojejunal tube plus intravenous… changes death (during length of initial hospital stay; ITT) compared with standard parenteral nutrition (very low certainty).

• Nutritional interventions for liver‐transplanted patients 2012 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 30 participants
  Very low

Enteral nutrition via nasojejunal tube plus intravenous glutamine‐dipeptide supplementation vs parenteral nutrition

It is very uncertain whether enteral nutrition via nasojejunal tube plus intravenous… changes infection (ITT) ‐ mycotic infection compared with standard parenteral nutrition (very low certainty).

• Nutritional interventions for liver‐transplanted patients 2012 · Cochrane Headline outcomes only
  OR 0.19 [0.02, 1.31]
  1 study · 30 participants
  Very low

Enteral nutrition via nasojejunal tube plus intravenous glutamine‐dipeptide supplementation vs parenteral nutrition

It is very uncertain whether enteral nutrition via nasojejunal tube plus intravenous… changes infection (ITT) ‐ infection (overall) compared with standard parenteral nutrition (very low certainty).

• Nutritional interventions for liver‐transplanted patients 2012 · Cochrane Headline outcomes only
  OR 0.35 [0.06, 1.84]
  1 study · 30 participants
  Very low

Enteral nutrition via nasojejunal tube plus intravenous glutamine‐dipeptide supplementation vs parenteral nutrition

It is very uncertain whether enteral nutrition via nasojejunal tube plus intravenous… changes acute rejection (ITT) compared with standard parenteral nutrition (very low certainty).

• Nutritional interventions for liver‐transplanted patients 2012 · Cochrane Headline outcomes only
  OR 0.21 [0.004, 2.49]
  1 study · 30 participants
  Very low

Enteral nutrition via nasojejunal tube plus intravenous glutamine‐dipeptide supplementation vs parenteral nutrition

• Nutritional interventions for liver‐transplanted patients 2012 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 30 participants
  Very low

Enteral nutrition via nasojejunal tube plus intravenous glutamine‐dipeptide supplementation vs parenteral nutrition

• Nutritional interventions for liver‐transplanted patients 2012 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 30 participants
  Very low

Enteral nutrition via nasojejunal tube plus intravenous glutamine‐dipeptide supplementation vs parenteral nutrition

• Nutritional interventions for liver‐transplanted patients 2012 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 30 participants
  Very low

Parenteral nutrition with alanyl‐glutamine, protein, fat, carbohydrates and branched‐chain amino acids vs 5% dextrose and normal saline

It is very uncertain whether parenteral nutrition with alanyl‐glutamine, protein, fat,… changes 1‐year‐survival compared with 5% dextrose and normal saline (very low certainty).

• Nutritional interventions for liver‐transplanted patients 2012 · Cochrane Headline outcomes only
  OR 0.29 [5e-04, 4.03]
  1 study · 43 participants
  Very low

Parenteral nutrition with alanyl‐glutamine, protein, fat, carbohydrates and branched‐chain amino acids vs 5% dextrose and normal saline

It is very uncertain whether parenteral nutrition with alanyl‐glutamine, protein, fat,… changes 3‐year‐survival compared with 5% dextrose and normal saline (very low certainty).

• Nutritional interventions for liver‐transplanted patients 2012 · Cochrane Headline outcomes only
  OR 0.76 [0.18, 3.18]
  1 study · 43 participants
  Very low

Intervention not reported

The intervention showed no clear difference in death prior to hospital discharge (high certainty).

• Glutamine supplementation to prevent morbidity and mortality in preterm infants 2016 · Cochrane Headline outcomes only
  RR 0.97 [0.8, 1.17]
  12 studies · 2877 participants
  High

Intervention not reported

The intervention showed no clear difference in neurodevelopmental impairment (low certainty).

• Glutamine supplementation to prevent morbidity and mortality in preterm infants 2016 · Cochrane Headline outcomes only
  RR 1.07 [0.59, 1.92]
  1 study · 72 participants
  Low

Intervention not reported

The intervention showed no clear difference in invasive infection (moderate certainty).

• Glutamine supplementation to prevent morbidity and mortality in preterm infants 2016 · Cochrane Headline outcomes only
  RR 0.94 [0.86, 1.04]
  11 studies · 2815 participants
  Moderate

Intervention not reported

The intervention showed no clear difference in necrotising enterocolitis (moderate certainty).

• Glutamine supplementation to prevent morbidity and mortality in preterm infants 2016 · Cochrane Headline outcomes only
  RR 0.83 [0.66, 1.06]
  11 studies · 2849 participants
  Moderate