Fish oil lipid emulsion (LE) vs non‐fish oil LE
Growth velocity, head circumference, mm/d, end of intervention · parenterally fed preterm infants with cholestasis
1 finding from 1 review
- no estimate extracted1 study · 16 participantsVery low
Findings
What do systematic reviews say?
51 questions · 52 findings · 3 reviews · Neonatal
No studies found 0 · 0%GRADE not reported 7 · 13.5%Very low 21 · 40.4%Low 24 · 46.2%Moderate 0 · 0%High 0 · 0%
Fish oil lipid emulsion (LE) vs non‐fish oil LE
Death of baby (up to discharge) · parenterally fed preterm infants with cholestasis
It is very uncertain whether fish oil lipid emulsion (LE) changes death before discharge – MOFS‐LE vs S‐LE – Pure F‐LE vs IL compared with non‐fish oil LE (very low certainty).
1 finding from 1 review
- RR 0.24 [0.03, 1.87]2 studies · 40 participantsVery low
Fish oil lipid emulsion (LE) vs non‐fish oil LE
Any sepsis – MOFS‐LE vs S‐LE – Pure F‐LE vs IL · parenterally fed preterm infants with cholestasis
It is very uncertain whether fish oil lipid emulsion (LE) changes any sepsis – MOFS‐LE vs S‐LE – Pure F‐LE vs IL compared with non‐fish oil LE (very low certainty).
1 finding from 1 review
- RR 1.21 [0.5, 2.92]2 studies · 40 participantsVery low
Fish oil lipid emulsion (LE) vs non‐fish oil LE
Conjugated bilirubin levels · parenterally fed preterm infants with cholestasis
1 finding from 1 review
- no estimate extracted1 study · 24 participantsLow
Fish oil lipid emulsion (LE) vs non‐fish oil LE
Death of baby (up to discharge) · Parenterally fed preterm infants
Fish oil lipid emulsion (LE) showed no clear difference in death before discharge – MOFS‐LE vs S‐LE compared with non‐fish oil LE (low certainty).
1 finding from 1 review
- RR 1.24 [0.81, 1.9]9 studies · 855 participantsLow
Fish oil lipid emulsion (LE) vs non‐fish oil LE
Oxygen requirement at 36 weeks' postmenstrual age · Parenterally fed preterm infants
Fish oil lipid emulsion (LE) showed no clear difference in CLD (oxygen requirement at 36 weeks' postmenstrual age) – MOFS‐LE vs… compared with non‐fish oil LE (low certainty).
1 finding from 1 review
- RR 1 [0.75, 1.34]6 studies · 581 participantsLow
Fish oil lipid emulsion (LE) vs non‐fish oil LE
Conjugated bilirubin levels · Parenterally fed preterm infants
1 finding from 1 review
- no estimate extracted8 studies · 673 participantsLow
Fish oil lipid emulsion (LE) vs non‐fish oil LE
PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – pure F‐LE vs S‐LE · parenterally fed term and late preterm infants with surgical conditions
It is very uncertain whether fish oil LE changes PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) Pure F‐LE vs S‐LE compared with non‐fish oil LE (very low certainty).
1 finding from 1 review
- Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes onlyRR 1.11 [0.08, 15.28]1 study · 19 participantsVery low
Fish oil lipid emulsion (LE) vs non‐fish oil LE
Resolution of PNALD/cholestasis (conjugated bilirubin less than2 mg/dL) Pure F‐LE vs S‐LE · parenterally fed term and late preterm infants
It is very uncertain whether fish oil LE changes resolution of PNALD/cholestasis (conjugated bilirubin less than2… compared with non‐fish oil LE (very low certainty).
1 finding from 1 review
- Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes onlyRR 5.6 [0.34, 93.35]1 study · 16 participantsVery low
Fish oil lipid emulsion (LE) vs non‐fish oil LE
Growth · parenterally fed term and late preterm infants
1 finding from 1 review
- Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes onlyno estimate extracted1 study · 16 participantsVery low
Fish oil lipid emulsion (LE) vs non‐fish oil LE
Any sepsis (clinical and/or culture positive) · parenterally fed term and late preterm infants
It is very uncertain whether fish oil LE changes any sepsis (clinical or culture positive (or both)) MOFS‐LE vs S‐LE… compared with non‐fish oil LE (very low certainty).
1 finding from 1 review
- Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes onlyRR 1.21 [0.5, 2.92]2 studies · 40 participantsVery low
Fish oil lipid emulsion (LE) vs non‐fish oil LE
Hypertriglyceridaemia · parenterally fed term and late preterm infants
It is very uncertain whether fish oil LE changes hypertriglyceridaemia compared with non‐fish oil LE (very low certainty).
1 finding from 1 review
- Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes onlyRR 0.79 [0.3, 2.09]1 study · 24 participantsVery low
Fish oil lipid emulsion (LE) vs non‐fish oil LE
Conjugated bilirubin levels · parenterally fed term and late preterm infants
1 finding from 1 review
- Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes onlyno estimate extracted1 study · 24 participantsLow
Fish oil lipid emulsion (LE) vs non‐fish oil LE
ALP U/L · parenterally fed term and late preterm infants
1 finding from 1 review
- Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes onlyno estimate extracted1 study · 24 participantsLow
Fish oil lipid emulsion (LE) vs non‐fish oil LE
Rate of change of conjugated bilirubin · parenterally fed term and late preterm infants
1 finding from 1 review
- Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes onlyno estimate extracted1 study · 16 participantsVery low
Fish oil lipid emulsion (LE) vs non‐fish oil LE
Mortality before hospital discharge · parenterally fed term and late preterm infants
It is very uncertain whether fish oil LE changes death before discharge compared with non‐fish oil LE (very low certainty).
1 finding from 1 review
- Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes onlyRR 0.24 [0.03, 1.87]2 studies · 40 participantsVery low
Fish oil lipid emulsion (LE) vs non‐fish oil LE
Parenteral nutrition‐associated liver disease/cholestasis · parenterally fed term and late preterm infants with surgical conditions
Fish oil LE showed no clear difference in PNALD/cholestasis (any definition) compared with non‐fish oil LE (low certainty).
1 finding from 1 review
- Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes onlyRR 1.2 [0.38, 3.76]2 studies · 68 participantsLow
Fish oil lipid emulsion (LE) vs non‐fish oil LE
Culture‐positive sepsis · parenterally fed term and late preterm infants with surgical conditions
It is very uncertain whether fish oil LE changes culture‐positive sepsis compared with non‐fish oil LE (very low certainty).
1 finding from 1 review
- Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes onlyRR 1.05 [0.47, 2.34]2 studies · 51 participantsVery low
Fish oil lipid emulsion (LE) vs non‐fish oil LE
Hypertriglyceridaemia · parenterally fed term and late preterm infants with surgical conditions
1 finding from 1 review
- Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes onlyno estimate extracted2 studies · 68 participantsGRADE not reported
Fish oil lipid emulsion (LE) vs non‐fish oil LE
Conjugated bilirubin levels · parenterally fed term and late preterm infants with surgical conditions
1 finding from 1 review
- Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes onlyno estimate extracted2 studies · 38 participantsGRADE not reported