Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

47 questions · 47 findings · 7 reviews · Kidney and Transplant

No studies found 10 · 21.3%GRADE not reported 0 · 0%Very low 8 · 17%Low 19 · 40.4%Moderate 9 · 19.1%High 1 · 2.1%

Calcineurin inhibitors ± oral steroids vs oral steroids alone

Adverse effects: obesity or Cushing's Syndrome · minimal change disease in adults with nephrotic syndrome

Calcineurin inhibitors ± oral steroids may leads to lower adverse effects: obesity or Cushing's Syndrome compared with oral steroids alone (low certainty).

1 finding from 1 review

Cyclosporin plus prednisolone vs prednisolone

Adverse effects: number needing cytotoxic agents · SSNS in children

It is very uncertain whether cyclosporin plus prednisolone changes adverse effects: number needing cytotoxic agents compared with prednisolone alone (very low certainty).

1 finding from 1 review

Rituximab (B cell) + steroid vs steroids

Graft loss or death with a functioning graft · kidney transplant recipients: first rejection episode

Rituximab (B cell) + steroid showed no clear difference in graft loss or death with a functioning graft compared with steroid alone (moderate certainty).

1 finding from 1 review