Intervention not reported
Moderate to severe exacerbations ‐ TRIPLE vs DUAL№ of participants: 8173(5 RCTs)
The intervention leads to lower moderate to severe exacerbations ‐ TRIPLE vs DUAL№ of participants:… (high certainty).
1 finding from 1 review
Intervention not reported
CFB in ACQ at 3 months ‐ TRIPLE vs DUAL№ of participants: 1535(1 RCT)
1 finding from 1 review
no estimate extracted
1 study · 3 participants
Moderate
Intervention not reported
CFB in ACQ at 6 months ‐ TRIPLE vs DUAL№ of participants: 5408(4 RCTs)
1 finding from 1 review
Intervention not reported
CFB in ACQ at 12 months ‐ DUAL vs TRIPLE№ of participants: 4253(4 RCTs)
1 finding from 1 review
Intervention not reported
CFB in AQLQ at 6 months ‐ TRIPLE vs DUAL№ of participants: 907(2 RCTs)
1 finding from 1 review
Intervention not reported
CFB in AQLQ at 12 months ‐ TRIPLE vs DUAL№ of participants: 3623(3 RCTs)
1 finding from 1 review
Rate of moderate or severe exacerbations Eosinophilic phenotype · patients with chronic obstructive pulmonary disease
Mepolizumab 100 mg leads to lower rate of moderate or severe exacerbations Eosinophilic phenotype compared with placebo (high certainty).
1 finding from 1 review
Rate of moderate or severe exacerbations Eosinophilic phenotype · patients with chronic obstructive pulmonary disease
Mepolizumab 300 mg showed no clear difference in rate of moderate or severe exacerbations Eosinophilic phenotype compared with placebo (moderate certainty).
1 finding from 1 review
Time to first moderate or severe exacerbation Eosinophilic phenotype · patients with chronic obstructive pulmonary disease
Mepolizumab 300 mg probably leads to lower time to first moderate or severe exacerbation Eosinophilic phenotype compared with placebo (moderate certainty).
1 finding from 1 review
Rate of exacerbations with ED visit or hospitalisations Eosinophilic phenotype · patients with chronic obstructive pulmonary disease
Mepolizumab 300 mg showed no clear difference in rate of exacerbations with ED visit or hospitalisations Eosinophilic… compared with placebo (moderate certainty).
1 finding from 1 review
Serious adverse events · patients with chronic obstructive pulmonary disease
Mepolizumab 300 mg showed no clear difference in serious adverse events compared with placebo (moderate certainty).
1 finding from 1 review
QoL · patients with chronic obstructive pulmonary disease
1 finding from 1 review
Exacerbations · patients with chronic obstructive pulmonary disease
Mepolizumab 750 mg showed no clear difference in number of participants experiencing an exacerbation within 6 months compared with placebo (low certainty).
2 findings from 1 review
Odds ratio 0.43 [0.06, 2.97]
1 study · 18 participants
Low
Odds ratio 9 [0.75, 108.31]
1 study · 18 participants
Low
Serious adverse events · patients with chronic obstructive pulmonary disease
Mepolizumab 750 mg showed no clear difference in serious adverse events compared with placebo (low certainty).
1 finding from 1 review
Health‐related quality of life (HRQL) · patients with chronic obstructive pulmonary disease
1 finding from 1 review
Lung function (FEV₁) · patients with chronic obstructive pulmonary disease
1 finding from 1 review
Moderate‐to‐severe exacerbations (rate) · patients with chronic obstructive pulmonary disease
Mepolizumab 100 mg showed no clear difference in rate of moderate or severe exacerbations All participants compared with placebo (moderate certainty).
1 finding from 1 review
Rate of moderate or severe exacerbations Eosinophils ≥ 220/μL · patients with chronic obstructive pulmonary disease
Benralizumab 10 mg showed no clear difference in rate of moderate or severe exacerbations Eosinophils ≥ 220/μL compared with placebo (moderate certainty).
1 finding from 1 review
Rate of moderate or severe exacerbations Eosinophils < 220/μL · patients with chronic obstructive pulmonary disease
Benralizumab 10 mg showed no clear difference in rate of moderate or severe exacerbations Eosinophils < 220/μL compared with placebo (moderate certainty).
1 finding from 1 review
Rate of severe exacerbations requiring hospitalisation Eosinophils ≥ 220/μL · patients with chronic obstructive pulmonary disease
Benralizumab 10 mg probably leads to lower rate of severe exacerbations requiring hospitalisation Eosinophils ≥… compared with placebo (moderate certainty).
1 finding from 1 review