Findings

What do systematic reviews say?

32 questions · 32 findings · 3 reviews · Developmental, Psychosocial and Learning Problems

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No studies found 9 · 28.1%GRADE not reported 0 · 0%Very low 12 · 37.5%Low 8 · 25%Moderate 2 · 6.3%High 1 · 3.1%

Donepezil vs placebo

Carer stress · people with Down syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for cognitive decline in people with Down syndrome 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Donepezil vs placebo

Institutional/home care · people with Down syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for cognitive decline in people with Down syndrome 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Donepezil vs placebo

Death · people with Down syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for cognitive decline in people with Down syndrome 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Memantine vs placebo

Secondary outcome measure: cognitive abilities at the end of · people with Down syndrome

1 finding from 1 review

Pharmacological interventions for cognitive decline in people with Down syndrome 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 184 participants
Low

Memantine vs placebo

Behavioural problems: overall · people with Down syndrome

1 finding from 1 review

Pharmacological interventions for cognitive decline in people with Down syndrome 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 186 participants
Low

Memantine vs placebo

Adverse events · people with Down syndrome

Comparison 2: memantine showed no clear difference in adverse events compared with placebo (low certainty).

1 finding from 1 review

Pharmacological interventions for cognitive decline in people with Down syndrome 2015 · Cochrane Headline outcomes only
OR 0.45 [0.18, 1.17]
2 studies · 211 participants
Low

Intervention not reported

Age of onset of independent walking (months) · children under six years with cerebral palsy or Down syndrome or at risk of neuromotor delay

1 finding from 1 review

Treadmill interventions in children under six years of age at risk of neuromotor delay 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 58 participants
Moderate

Intervention not reported

Age of onset of walking with assistance (days in study) · children under six years with cerebral palsy or Down syndrome or at risk of neuromotor delay

1 finding from 1 review

Treadmill interventions in children under six years of age at risk of neuromotor delay 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 58 participants
Very low

Intervention not reported

Gross motor function (GMFM) (%) · children under six years with cerebral palsy or Down syndrome or at risk of neuromotor delay

1 finding from 1 review

Treadmill interventions in children under six years of age at risk of neuromotor delay 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 36 participants
Moderate

Intervention not reported

Gross motor function related to standing (GMFM) ‐ Dimension D (%) · children under six years with cerebral palsy or Down syndrome or at risk of neuromotor delay

1 finding from 1 review

Treadmill interventions in children under six years of age at risk of neuromotor delay 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 32 participants
Low

Intervention not reported

Gross motor function related to walking, running and jumping (GMFM) ‐ Dimension E (%) · children under six years with cerebral palsy or Down syndrome or at risk of neuromotor delay

1 finding from 1 review

Treadmill interventions in children under six years of age at risk of neuromotor delay 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 32 participants
Low

Intervention not reported

Velocity (m/s) · children under six years with cerebral palsy or Down syndrome or at risk of neuromotor delay

1 finding from 1 review

Treadmill interventions in children under six years of age at risk of neuromotor delay 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 32 participants
High