Mean relative percentage in FVC (L) at 3 months · children with cystic fibrosis
Dornase alfa daily showed no clear difference in mean relative percentage in FVC (L) at 3 months compared with alternate days (low certainty).
1 finding from 1 review
HRQoL ‐ all domains (change from baseline) Scale: age‐appropriate versions of the CFQ‐R questionnaire · children and young adults with CF
1 finding from 1 review
Lung function: FEV1 mL (percentage change from baseline) · children and young adults with CF
It is very uncertain whether summary of findings ‐ Inhaled mannitol plus dornase alfa changes lung function: FEV1mL (percentage change from baseline) compared with dornase alfa (very low certainty).
1 finding from 1 review
FEV1 % predicted · children and young adults with CF
The review found no eligible studies for this question.
1 finding from 1 review
FVC · children and young adults with CF
It is very uncertain whether summary of findings ‐ Inhaled mannitol plus dornase alfa changes lung function: FVC mL (percentage change from baseline) compared with dornase alfa (very low certainty).
1 finding from 1 review
Lung function: FEF25‐75 mL/s (percentage change from baseline) · children and young adults with CF
It is very uncertain whether summary of findings ‐ Inhaled mannitol plus dornase alfa changes lung function: FEF25-75 mL/s (percentage change from baseline) compared with dornase alfa (very low certainty).
1 finding from 1 review
Adverse events relating to treatment Scale: mild, moderate, severe and total · children and young adults with CF
1 finding from 1 review
FEV1 % predicted: absolute change from baseline · adults and children with cystic fibrosis
It is very uncertain whether inhalation of dornase alfa before changes FEV1 (% predicted) change from baseline compared with after airway clearance techniques (very low certainty).
1 finding from 1 review
MD 0.83
102 participants
Very low
FVC (% predicted) Change from baseline · adults and children with cystic fibrosis
Inhalation of dornase alfa before showed no clear difference in FVC (% predicted) change from baseline compared with after airway clearance techniques (low certainty).
1 finding from 1 review
MD 1.06
77 participants
Low
Measures of QoL and symptom scores · adults and children with cystic fibrosis
1 finding from 1 review
no estimate extracted
102 participants
Very low
FEF25-75 · adults and children with cystic fibrosis
Inhalation of dornase alfa before showed no clear difference in FEF25-75 (% predicted) compared with after airway clearance techniques (low certainty).
1 finding from 1 review
no estimate extracted
25 participants
Low
Adverse effects · adults and children with cystic fibrosis
1 finding from 1 review
no estimate extracted
102 participants
Very low
Treatment time · children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Quality of life · children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Serum deposition Cmax · children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events · children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
FEV1 · children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Time to next exacerbation · children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Participant satisfaction or preference · children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Treatment time (minutes) · adults and children with cystic fibrosis
1 finding from 1 review