Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

149 questions · 159 findings · 18 reviews

No studies found 21 · 13.2%GRADE not reported 8 · 5%Very low 33 · 20.8%Low 62 · 39%Moderate 29 · 18.2%High 6 · 3.8%

Perineural dexamethasone vs placebo

Incidence of serious adverse events (we used the NIH definition of adverse events. A serious event includes death, a life‐threatening event that requires hospitalization or prolonged hospitalization, disability or congenital anomaly) · participants undergoing surgery with peripheral nerve block
1 finding from 1 review

Perineural dexamethasone vs placebo

Postoperative pain intensity in the immediate postobturation period (up to 72 hours), continuous (VAS) · participants undergoing surgery with peripheral nerve block
3 findings from 1 review

Intravenous dexamethasone vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · participants undergoing surgery with peripheral nerve block
3 findings from 1 review

Intravenous dexamethasone vs placebo

Incidence of serious adverse events (we used the NIH definition of adverse events. A serious event includes death, a life‐threatening event that requires hospitalization or prolonged hospitalization, disability or congenital anomaly) · participants undergoing surgery with peripheral nerve block

The review found no eligible studies for this question.

1 finding from 1 review

Dexamethasone: oral vs intramuscular – fetal/neonatal outcomes

Any known death after randomisation (fetal, neonatal, child, child as adult) · women at risk of preterm birth

It is very uncertain whether dexamethasone: oral changes any known death after randomisation (fetal, neonatal, child, child… compared with intramuscular – fetal/neonatal outcomes (very low certainty).

1 finding from 1 review

Dexamethasone: oral vs intramuscular – fetal/neonatal outcomes

Respiratory distress syndrome · women at risk of preterm birth

It is very uncertain whether dexamethasone: oral changes respiratory distress syndrome compared with intramuscular – fetal/neonatal outcomes (very low certainty).

1 finding from 1 review

Dexamethasone: oral vs intramuscular – fetal/neonatal outcomes

Intraventricular haemorrhage · women at risk of preterm birth

It is very uncertain whether dexamethasone: oral changes intraventricular haemorrhage compared with intramuscular – fetal/neonatal outcomes (very low certainty).

1 finding from 1 review

Dexamethasone: oral vs intramuscular – fetal/neonatal outcomes

Necrotising enterocolitis · women at risk of preterm birth

It is very uncertain whether dexamethasone: oral changes necrotising enterocolitis compared with intramuscular – fetal/neonatal outcomes (very low certainty).

1 finding from 1 review